The Role of Chromenes in Drug Discovery and Development

Chromenes as Anticancer Agents

Author(s): Parul Grover, Harmandeep Kaur Gulati, Jasha Momo H. Anál and Debaraj Mukherjee * .

Pp: 190-214 (25)

DOI: 10.2174/9789815124330123010011

* (Excluding Mailing and Handling)

Abstract

Heterocyclic compounds hold an important place in the realm of medicinal chemistry due to their vast pharmacological and therapeutic significance. Worldwide, cancer is the leading cause of death, and developing an appropriate treatment for the management of cancer is a challenge. Efforts are being made continuously to search for a suitable medicinal agent to treat cancer. Chromene (benzopyran) is an important scaffold and is also considered a privileged pharmacophore. This scaffold also appears as an important structural component in various natural products. The various substituted and fused chromenes display propitious activity against various types of cancer. This chapter highlights the latest advancements from the year 2015 to date on chromene-based molecules that have anticancer activities. A subpart briefing natural chromenes containing anticancer potential is also incorporated. 

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