Anticancer Immunity: Reviewing the Potential of Probiotics

Probiotics-based Anticancer Immunity In Lymphomas

Author(s): Archana Chaudhari, Swati Patel and Mitesh Kumar Dwivedi * .

Pp: 118-150 (33)

DOI: 10.2174/9789815165135123040009

* (Excluding Mailing and Handling)

Abstract

The gut microbiome can play an important role in maintaining homeostasis in the human body. An imbalance in the gut microbiome can lead to pro-inflammatory immune responses and the initiation of disease processes, including cancer. Lymphocytes play a significant role in the reaction to bacterial colonization, mainly by prompting a safe reaction to initiation. Most immunologically inhabitant cells are continually signaled by dendritic cells or other antigen-presenting cells that collect intestinal samples. Therefore, the microbiota is a pivotal contributor to developing lymphoma, and specific changes to microbiota composition could help prevent the risk. Microbial morphology can affect and control humanoids. The difference in the composition of these microbes is associated with tumor development. Moreover, with the increased exploration and knowledge of the connection between human microbiota and carcinogenesis, the use of these findings to predict, prevent, or diagnose lymphomas has attracted great attention. Probiotics have gained increasing medical significance due to their beneficial effect on the human body, which has been linked to the prevention and support of the treatment of many chronic diseases, including cancer, in the absence of side effects. Chemotherapy and immunotherapy are extensively used for the treatment of lymphomas. But these treatments have various side effects. There is much evidence that probiotics can help in preventing cancer and support anticancer therapy. This chapter presents the latest advances in research into the effectiveness of probiotics in the prevention and treatment support of lymphoma. In addition, the chapter also describes the potential mechanisms of probiotic chemoprevention and the advisability of using probiotics in the prevention of lymphoma. 

Related Journals
Related Books
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version207msRequest Duration26MBMemory UsageGET chapter/{id}/{param?}Route
  • warninglog[21:24:42] LOG.warning: Optional parameter $id declared before required parameter $request is implic...
  • Booting (115ms)time
  • Application (91.9ms)time
  • 1 x Booting (55.6%)
    115ms
    1 x Application (44.4%)
    91.90ms
    12 templates were rendered
    • ebook.chapter_detailschapter_details.blade.php#?blade
    • layouts.chapter_header_sectionchapter_header_section.blade.php#?blade
    • ebook.chapter_top_bannerchapter_top_banner.blade.php#?blade
    • ebook.chapter_bottom_bannerchapter_bottom_banner.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET chapter/{id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ChapterController@GetChapterDetails
    namespace
    App\Http\Controllers
    where
    as
    chapter
    file
    app/Http/Controllers/ChapterController.php:1350-1704
    19 statements were executed24.78ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('59349287','',1,1740345882,1740345882) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740345882
      870μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('59349287','/chapter/19588',1,1740345882,1740345882)
      130μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59349287 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59349287) limit 1
      12.91msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59349287
      • 1: 59349287
      • 2: 59349287
      • 3: 59349287
      • 4: 59349287
      • 5: 59349287
      • 6: 59349287
      • 7: 59349287
      • 8: 59349287
      • 9: 59349287
      • 10: 59349287
      • 11: 59349287
      • 12: 59349287
      • 13: 59349287
      • 14: 59349287
      • 15: 59349287
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select * from `chapter` where `chapter_id` = '19588' limit 1
      320μsalphaeurekaselec_live_10_06_2022ChapterController.php#1406
      Bindings
      • 0: 19588
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1406
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`chapter_id` = '19588' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.19msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 19588
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ChapterController.php:1411
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `keywords` where `chapter_id` = '19588'
      210μsalphaeurekaselec_live_10_06_2022ChapterController.php#1415
      Bindings
      • 0: 19588
      Backtrace
      • 15. app/Http/Controllers/ChapterController.php:1415
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select * from `ebook` where `ebook_id` = 1167 limit 1
      250μsalphaeurekaselec_live_10_06_2022ChapterController.php#1430
      Bindings
      • 0: 1167
      Backtrace
      • 16. app/Http/Controllers/ChapterController.php:1430
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1167) and se.ebook_id!=1167 and v.ebook_status='1'
      2.41msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/ChapterController.php:1434
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1167) and se.ebook_id!=1167 and v.ebook_status='1' limit 10 offset 0
      720μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/ChapterController.php:1434
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1167)
      400μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/ChapterController.php:1435
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=1167) limit 10 offset 0
      430μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/ChapterController.php:1435
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = 3528 and `e`.`is_uploaded` = 1
      530μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 3528
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/ChapterController.php:1438
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 1167 and ebook_volume_id <> 3528 limit 1
      250μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 1167
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/ChapterController.php:1462
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '19588' and content_type = 'c' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      320μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from ebook_access where content_type_id = '3528' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      310μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3528) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3528) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"ebook_volume" as access_level,"" as chapter_id from `user_access_ebook_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3528)
      630μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 19588) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 19588) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59349287 and j.to_ip >=59349287 )) and ((j.from_date <= 1740345882 and j.to_date >= 1740345882 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 19588)
      580μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3528 and `b`.`banner_from_date` <= 1740345882 and `b`.`banner_to_date` >= 1740345882 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3528
      • 3: 1740345882
      • 4: 1740345882
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='fa3bb98f25b05df60ff31177715143a5'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        j0sIiMegQylzGe6jKT12c5f8q5F9nOYjIh20y54j
        uc_cart_id
        fa3bb98f25b05df60ff31177715143a5
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/19588" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/19588
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Imk1U1NWcWVNR2tLaWNiSFYrVEJrMnc9PSIsInZhbHVlIjoiaFdKTlhVcTJDSVFaYjFLRzFxVEkvTVJ0K0Y0ZUtmZmJKRHBDS1dmaHJoTT0iLCJtYWMiOiIyMTIxYmRkOGZmOTkwNmZmYjJkOGMxOTEzNWRjN2Q1YjZiN2RjMzQ5NTJlOGVjYjYxNzg0Y2M3MTM1NmQxZTIyIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Imk1U1NWcWVNR2tLaWNiSFYrVEJrMnc9PSIsInZhbHVlIjoiaFdKTlhVcTJDSVFaYjFLRzFxVEkvTVJ0K0Y0ZUtmZmJKRHBDS1dmaHJoTT0iLCJtYWMiOiIyMTIxYmRkOGZmOTkw" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:24:42 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImRDOWFPREVpQ1JxK0FaYnVGdHZHSmc9PSIsInZhbHVlIjoiN1Z4RWppMlE2VE80ZU83SjlCY1V4MlZjN0dYQlhmWmxHMlNkeHI0NTRURm1OSE1qN1lta09qNVM2UVN0NnVMN2lDb0V2QTVKcldTRkNUTis1Q2pPU0JBL0xVL2JjTmZubmw1MkRlNFo4cCtrTmM5YS9xcjJnaTRoMEZHcktiVFIiLCJtYWMiOiI5NmJiMGYyMWQ2OThhOTNiYWZhNWZkZmMyMDhmOWJjOTc3YjVkODY1NDJjMTE4ZTU0ZDJiY2MyM2Y1YjM4M2NiIiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:24:42 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImRDOWFPREVpQ1JxK0FaYnVGdHZHSmc9PSIsInZhbHVlIjoiN1Z4RWppMlE2VE80ZU83SjlCY1V4MlZjN0dYQlhmWmxHMlNkeHI0NTRURm1OSE1qN1lta09qNVM2UVN0NnVMN2lDb0V2Q" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlZoQWRIL3VPLzJ1ZFluck9GYXBDRXc9PSIsInZhbHVlIjoiV2V0Tml6TFI0SnQxaXArNHpvNUxRRENJaWZMalR1NEEzbW9QMHZMYVdEdUZOKzU4UFIyOUpNZTJMOTVDUnl3YmtUd3NFRm9KYk9USXdNY3NFcitUdW9LMzdPQTMrQVlGSHpJRTQxcXk1KzFxRUFEeTNKK1RmaTZmQzJiUkhyMDIiLCJtYWMiOiIwOWFhNjczMjFlNTNlOTllZjNjZmQ5M2NmNGNiMWFjYjEyZmRmM2FiNjc2NmM5ODdhMDViNzVjZDZiMzMxNmU0IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlZoQWRIL3VPLzJ1ZFluck9GYXBDRXc9PSIsInZhbHVlIjoiV2V0Tml6TFI0SnQxaXArNHpvNUxRRENJaWZMalR1NEEzbW9QMHZMYVdEdUZOKzU4UFIyOUpNZTJ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImRDOWFPREVpQ1JxK0FaYnVGdHZHSmc9PSIsInZhbHVlIjoiN1Z4RWppMlE2VE80ZU83SjlCY1V4MlZjN0dYQlhmWmxHMlNkeHI0NTRURm1OSE1qN1lta09qNVM2UVN0NnVMN2lDb0V2QTVKcldTRkNUTis1Q2pPU0JBL0xVL2JjTmZubmw1MkRlNFo4cCtrTmM5YS9xcjJnaTRoMEZHcktiVFIiLCJtYWMiOiI5NmJiMGYyMWQ2OThhOTNiYWZhNWZkZmMyMDhmOWJjOTc3YjVkODY1NDJjMTE4ZTU0ZDJiY2MyM2Y1YjM4M2NiIiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:24:42 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImRDOWFPREVpQ1JxK0FaYnVGdHZHSmc9PSIsInZhbHVlIjoiN1Z4RWppMlE2VE80ZU83SjlCY1V4MlZjN0dYQlhmWmxHMlNkeHI0NTRURm1OSE1qN1lta09qNVM2UVN0NnVMN2lDb0V2Q" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlZoQWRIL3VPLzJ1ZFluck9GYXBDRXc9PSIsInZhbHVlIjoiV2V0Tml6TFI0SnQxaXArNHpvNUxRRENJaWZMalR1NEEzbW9QMHZMYVdEdUZOKzU4UFIyOUpNZTJMOTVDUnl3YmtUd3NFRm9KYk9USXdNY3NFcitUdW9LMzdPQTMrQVlGSHpJRTQxcXk1KzFxRUFEeTNKK1RmaTZmQzJiUkhyMDIiLCJtYWMiOiIwOWFhNjczMjFlNTNlOTllZjNjZmQ5M2NmNGNiMWFjYjEyZmRmM2FiNjc2NmM5ODdhMDViNzVjZDZiMzMxNmU0IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlZoQWRIL3VPLzJ1ZFluck9GYXBDRXc9PSIsInZhbHVlIjoiV2V0Tml6TFI0SnQxaXArNHpvNUxRRENJaWZMalR1NEEzbW9QMHZMYVdEdUZOKzU4UFIyOUpNZTJ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "j0sIiMegQylzGe6jKT12c5f8q5F9nOYjIh20y54j" "uc_cart_id" => "fa3bb98f25b05df60ff31177715143a5" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/19588" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:24:42GET/chapter/19588112192