Omics Technologies for Clinical Diagnosis and Gene Therapy: Medical Applications in Human Genetics

Integrated Bioinformatics and Computational Biology Approaches: Applications in Diagnosis and Therapeutics

Author(s): Fatima Shahid, Shifa Tariq Ashraf, Hayeqa Shahwar Awan, Amina Basheer and Amjad Ali * .

Pp: 114-136 (23)

DOI: 10.2174/9789815079517122010011

* (Excluding Mailing and Handling)

Abstract

The advent of bioinformatics and integrated biology approaches has given rise to new avenues of diagnostic and therapeutic regimes. Living systems have been explored to identify disease-associated biomarkers that facilitate the early diagnosis of perilous medical conditions. Likewise, gene networks are pondered upon to obtain better insights into biochemical systems that can assist in the prediction and testing of the effects of various interactions within the systems. Genomics and proteomics-based approaches are being explored to facilitate the early diagnosis of cancers, shifting the paradigm towards noninvasive diagnostic alternatives. Bioinformatics has also fueled pharmacogenomics and pharmacogenetics-based strategies that have in turn contributed to the development of personalized medications. Similarly, the reverse vaccinology approach has emerged as a prominent option to combat deadly pathogens that were otherwise unrestrainable. This chapter highlights the fruits of integrated bioinformatics in diagnosing and treating detrimental conditions.


Keywords: Integrated bioinformatics, Precision medicine, Computational diagnostic tools, In silico Therapeutics, Reverse vaccinology.

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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59274385 and j.to_ip >=59274385 )) and ((j.from_date <= 1739834586 and j.to_date >= 1739834586 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17959) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59274385 and j.to_ip >=59274385 )) and ((j.from_date <= 1739834586 and j.to_date >= 1739834586 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17959) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59274385 and j.to_ip >=59274385 )) and ((j.from_date <= 1739834586 and j.to_date >= 1739834586 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 17959)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3416 and `b`.`banner_from_date` <= 1739834586 and `b`.`banner_to_date` >= 1739834586 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.25msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3416
      • 3: 1739834586
      • 4: 1739834586
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='d2b497dc971b06aef394b04b621e3a2b'
      300μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        Mn6Og3trpRPmL4JJZ37JQsvHRjkLnvu8BVtg9LQW
        uc_cart_id
        d2b497dc971b06aef394b04b621e3a2b
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/17959" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/17959
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 17 Feb 2025 23:23:06 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjBRK09SenNJTjhGWUQ4cGxLWURmTkE9PSIsInZhbHVlIjoiSHd2Zk0zZmtnYm84NlVSSlJvaWxOWnVvMm9FR1RSNkRQUDhDUWxHRlVNVGdmWDlvaWp3bHJxbXArbUc0MDZicERMbFVtNk9zaEc2YjlvVXBvZG45ckZjN0d1Q0JBSlhhcmk3cTNaalE1eTh0SkxnaHhpSXVna3ZJOXNMSzVEeGYiLCJtYWMiOiI3MGE2ZGUxZWRlZGJkZTY4YzA2ZWZlYWUxYWRkMTVjZTUxZDMxZDJjYjAyOWMyMTg4MGY2ZGUzNjdjYjBhNWQ4IiwidGFnIjoiIn0%3D; expires=Thu, 20 Feb 2025 11:23:06 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IjBRK09SenNJTjhGWUQ4cGxLWURmTkE9PSIsInZhbHVlIjoiSHd2Zk0zZmtnYm84NlVSSlJvaWxOWnVvMm9FR1RSNkRQUDhDUWxHRlVNVGdmWDlvaWp3bHJxbXArbUc0MDZicERMbFVtN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IktJSy9JdlNHUm15c2t6b29qVXY1MkE9PSIsInZhbHVlIjoiNmx3Yk5YUzE4d2kyUTFEOWFiUDgxZThaempsL1UzRk9PUjcwU0pHMkVyeXA3MGIzV2ozd1REWmxPNkd4QVNpWU4ySXZvSUdkRTJySFhxTzFGTlZhQW1JSzg5Mk9udTFRalh6TGozZk1KRjl3Qy9SelArRkIvaWxPN0NhbEdlbUkiLCJtYWMiOiI0MzYyM2I0NWQ5YzY3MzM2MWI0OWYyMjEzOTlkN2Q5ZWI4NzZkNDgzNDhhYWQ1M2MyODA0OGVkOWFlMGFjNzkwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IktJSy9JdlNHUm15c2t6b29qVXY1MkE9PSIsInZhbHVlIjoiNmx3Yk5YUzE4d2kyUTFEOWFiUDgxZThaempsL1UzRk9PUjcwU0pHMkVyeXA3MGIzV2ozd1REWmx" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IjBRK09SenNJTjhGWUQ4cGxLWURmTkE9PSIsInZhbHVlIjoiSHd2Zk0zZmtnYm84NlVSSlJvaWxOWnVvMm9FR1RSNkRQUDhDUWxHRlVNVGdmWDlvaWp3bHJxbXArbUc0MDZicERMbFVtNk9zaEc2YjlvVXBvZG45ckZjN0d1Q0JBSlhhcmk3cTNaalE1eTh0SkxnaHhpSXVna3ZJOXNMSzVEeGYiLCJtYWMiOiI3MGE2ZGUxZWRlZGJkZTY4YzA2ZWZlYWUxYWRkMTVjZTUxZDMxZDJjYjAyOWMyMTg4MGY2ZGUzNjdjYjBhNWQ4IiwidGFnIjoiIn0%3D; expires=Thu, 20-Feb-2025 11:23:06 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IjBRK09SenNJTjhGWUQ4cGxLWURmTkE9PSIsInZhbHVlIjoiSHd2Zk0zZmtnYm84NlVSSlJvaWxOWnVvMm9FR1RSNkRQUDhDUWxHRlVNVGdmWDlvaWp3bHJxbXArbUc0MDZicERMbFVtN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IktJSy9JdlNHUm15c2t6b29qVXY1MkE9PSIsInZhbHVlIjoiNmx3Yk5YUzE4d2kyUTFEOWFiUDgxZThaempsL1UzRk9PUjcwU0pHMkVyeXA3MGIzV2ozd1REWmxPNkd4QVNpWU4ySXZvSUdkRTJySFhxTzFGTlZhQW1JSzg5Mk9udTFRalh6TGozZk1KRjl3Qy9SelArRkIvaWxPN0NhbEdlbUkiLCJtYWMiOiI0MzYyM2I0NWQ5YzY3MzM2MWI0OWYyMjEzOTlkN2Q5ZWI4NzZkNDgzNDhhYWQ1M2MyODA0OGVkOWFlMGFjNzkwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IktJSy9JdlNHUm15c2t6b29qVXY1MkE9PSIsInZhbHVlIjoiNmx3Yk5YUzE4d2kyUTFEOWFiUDgxZThaempsL1UzRk9PUjcwU0pHMkVyeXA3MGIzV2ozd1REWmx" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "Mn6Og3trpRPmL4JJZ37JQsvHRjkLnvu8BVtg9LQW" "uc_cart_id" => "d2b497dc971b06aef394b04b621e3a2b" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/17959" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-17 23:23:06GET/chapter/17959112197