Flavonoid Based Bioactive for Therapeutic Application in Neurological Disorders

Flavonoids belong to a class of natural, polyphenolic dietary compounds which modify the neuropathological state of the brain. Some flavonoids like quercetin and other, reduce the inflammation, carcinogenicity, and oxidation promotes neuroprotection and comprises the major component of cosmetics, medicinal and dietary supplements. Daily intake of flavonoids helps to mitigate the risk of several neurological disorders like Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, etc. Flavonoids exhibit their pharmacological effect through various mechanisms like cholinesterase inhibition, scavenging free radicals, memory enhancement via attenuation of amyloid plaques, tau targeting detoxification and neural antiinflammation. Administration of flavonoids to biological system has to pass through several biological checkpoints like first pass metabolism, intestinal absorption, and entry into blood brain barrier. Flavonoids exhibit difference in pharmacokinetic and pharmacodyanmic profile due to difference in their structures. Recent literature reports have proved promising therapeutic potential in neurological disorders. This chapter highlights the recent development of flavonoids prevailing in the field of neurodegenerative, its limitations and drug delivery approaches to encounter the challenges. 

Keywords: Flavonoids, Alzheimer’s, Parkinson's, Natural Biological, Neurodegenerative disorder.