Current Therapeutic Options and Challenges for MDR

Multiple-Drug Resistance (MDR) against many antibiotics and other therapeutic agents is a major concern for health care providers and researchers in the field. Due to tremendous rise in MDR cases, researchers are in search of potent therapeutic options or alternatives to overcome MDR. Here, in this chapter, we will discuss the current status of the common as well as advanced methods which have been developed so far for the treatment of MDR and also the challenges and opportunities in each of those methods. This chapter discusses common methods used for the treatment of MDR, i.e., major antibiotics used for the treatment of MDR bacteria and synergistic approaches by the combination of different antibiotics. Along with common treatments used against MDR bacteria, this chapter also discusses current treatments like antimicrobial peptides, anti-virulence compounds, phage therapy and drug repurposing approaches for MDR treatment.

Keywords: Allopathic medicines, Anti-microbial peptide, Antibiotics, Carbapenems, Multiple-drug resistance, Phage therapy.