Free Radical Biology in Alzheimer's Disease

Pp: 95-112 (18)

* (Excluding Mailing and Handling)

Understanding the pathological findings and pathogenesis of Alzheimer's

disease has been ever-expanding and challenging. Oxidative stress resulting from

excessive free radicals that can be scavenged by the antioxidant system of our body has

been implicated in the initiation and progression of the illness. Neuronal oxidative

stress can induce the formation of amyloid-beta (Aβ) protein, and it has been found that

Aβ is involved in several intracellular pathways that orchestrate the cellular oxidative

stress, resulting in a vicious cycle. Several risk factors can lead to AD by increasing

neuronal oxidative stress. Therapy based on increasing and reinforcing the antioxidant

defense against free radicals has shown promising results. New approaches are being

developed, such as interventions targeting mitochondria and drugs that act through

numerous mechanisms to address the various ways through which oxidative stress

causes AD.

Keywords: Amyloid-beta protein, Antioxidants, Oxidative stress, Risk factors.

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