The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo

Quantitation of Myocardial Perfusion using 15OWater PET: From a Research Tool to Clinical Routine

Author(s): Juhani Knuuti * .

Pp: 359-367 (9)

DOI: 10.2174/9781681088655122010033

* (Excluding Mailing and Handling)

Abstract

The application of 15O-water for cardiac PET perfusion imaging was one of
the main goals when this tracer was developed. However, the development of a method
from basic research to routine tool in clinical work takes a long time. With the case of
cardiac 15O-water PET it took 22-27 years from the initial plans to clinically accepted
tool. This is likely not unusual as the validation of new method and demonstrating the
clinical impact requires many studies and a long time. Eventually, the method has been
now included in the European clinical guidelines of chronic coronary syndromes as an
accepted clinical tool. This paper illustrates the development of the cardiac 15O-water
PET at Turku PET Centre, one of the pioneers in developing the method from bench to
bedside. Despite the current success, there are still many open issues, which warrant
further development and studies.


Keywords: Coronary artery disease, Cyclotron, Diabetes, Fractional flow reserve, Heart, Hypertension, Myocardium, Oxygen-15, Perfusion, Positron emission tomography, Quantitation.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
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      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316575447 and j.to_ip >=316575447 )) and ((j.from_date <= 1740526530 and j.to_date >= 1740526530 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16596) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316575447 and j.to_ip >=316575447 )) and ((j.from_date <= 1740526530 and j.to_date >= 1740526530 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16596) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316575447 and j.to_ip >=316575447 )) and ((j.from_date <= 1740526530 and j.to_date >= 1740526530 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 16596)
      590μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3314 and `b`.`banner_from_date` <= 1740526530 and `b`.`banner_to_date` >= 1740526530 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.04msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3314
      • 3: 1740526530
      • 4: 1740526530
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='019322fc86b4f0e521044abd9971d20f'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    11Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        5ymoJ80zuI3yFJanInkwev8gLDlcKxh9M0ELxGb1
        uc_cart_id
        019322fc86b4f0e521044abd9971d20f
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/16596" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/16596
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 23:35:30 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkhpREM2UEZoeFJUUHQxemt0MzBZZ1E9PSIsInZhbHVlIjoiOWlmcjV5YW5US2J2dit1c05iNjRrN1VmWkUzN1AvQ0NLZVVZUkkyN0JRS001czU4akhEWnhYT1lOQ3JFWU9uaVdrRUk3SlprbDVJZURoRjZ3QURlL3Nwc01RektvMkxtVW5Ba1BCaGNOcmswNjdrbFFwaVhueWp1bTlMYy9McWkiLCJtYWMiOiJkNTU1NmE0MzA4ZTA2ZGI2MjVkM2Y0NGRhY2Y0M2JmOTM0OGM0MTY5NDI1MDdiODY3NjNjZGNkNzhlZDZhMjExIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 11:35:30 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkhpREM2UEZoeFJUUHQxemt0MzBZZ1E9PSIsInZhbHVlIjoiOWlmcjV5YW5US2J2dit1c05iNjRrN1VmWkUzN1AvQ0NLZVVZUkkyN0JRS001czU4akhEWnhYT1lOQ3JFWU9uaVdrRUk3S" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikc1ZVF2S08vMGsxcFlzcWloUjVpSHc9PSIsInZhbHVlIjoialR3anltT2JVNjgvM25wcEY5ZnFsUzJSOHhMcjluekw0cUpmcTVCWGpmNzlLMERkVys5T25yK1MxaGRwV2xFVmJJc2tKSDZNd0ZvSFVNdkpVNURCaWVYWE9RY093aksreUpuYnRvTkpxRzNxcjR0UkxjTndKNE1mbGJRK0hFblciLCJtYWMiOiJjMzI2OTc1ZmVkMDJhMTE0ODkzYWRiN2JlNjUwMjExMTFkZTk1MTQ0NDA4YmJhZWI2OTU3NjQ3MDMwMTYwNDQzIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ikc1ZVF2S08vMGsxcFlzcWloUjVpSHc9PSIsInZhbHVlIjoialR3anltT2JVNjgvM25wcEY5ZnFsUzJSOHhMcjluekw0cUpmcTVCWGpmNzlLMERkVys5T25yK1M" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkhpREM2UEZoeFJUUHQxemt0MzBZZ1E9PSIsInZhbHVlIjoiOWlmcjV5YW5US2J2dit1c05iNjRrN1VmWkUzN1AvQ0NLZVVZUkkyN0JRS001czU4akhEWnhYT1lOQ3JFWU9uaVdrRUk3SlprbDVJZURoRjZ3QURlL3Nwc01RektvMkxtVW5Ba1BCaGNOcmswNjdrbFFwaVhueWp1bTlMYy9McWkiLCJtYWMiOiJkNTU1NmE0MzA4ZTA2ZGI2MjVkM2Y0NGRhY2Y0M2JmOTM0OGM0MTY5NDI1MDdiODY3NjNjZGNkNzhlZDZhMjExIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 11:35:30 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkhpREM2UEZoeFJUUHQxemt0MzBZZ1E9PSIsInZhbHVlIjoiOWlmcjV5YW5US2J2dit1c05iNjRrN1VmWkUzN1AvQ0NLZVVZUkkyN0JRS001czU4akhEWnhYT1lOQ3JFWU9uaVdrRUk3S" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikc1ZVF2S08vMGsxcFlzcWloUjVpSHc9PSIsInZhbHVlIjoialR3anltT2JVNjgvM25wcEY5ZnFsUzJSOHhMcjluekw0cUpmcTVCWGpmNzlLMERkVys5T25yK1MxaGRwV2xFVmJJc2tKSDZNd0ZvSFVNdkpVNURCaWVYWE9RY093aksreUpuYnRvTkpxRzNxcjR0UkxjTndKNE1mbGJRK0hFblciLCJtYWMiOiJjMzI2OTc1ZmVkMDJhMTE0ODkzYWRiN2JlNjUwMjExMTFkZTk1MTQ0NDA4YmJhZWI2OTU3NjQ3MDMwMTYwNDQzIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ikc1ZVF2S08vMGsxcFlzcWloUjVpSHc9PSIsInZhbHVlIjoialR3anltT2JVNjgvM25wcEY5ZnFsUzJSOHhMcjluekw0cUpmcTVCWGpmNzlLMERkVys5T25yK1M" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "5ymoJ80zuI3yFJanInkwev8gLDlcKxh9M0ELxGb1" "uc_cart_id" => "019322fc86b4f0e521044abd9971d20f" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/16596" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 23:35:30GET/chapter/165961121913