Abstract
Antihypertensives are one of the most consumed drugs worldwide. To
reduce pill burden, more than one class of antihypertensive drugs can be found in the
same tablet in a fixed-dose combination. In this chapter, an overview of about 35
papers reporting on the advanced sensor materials for the voltammetric simultaneous
determination of antihypertensive drugs will be presented. Special attention is given to
the strategies the authors used for enabling simultaneous determination. Several types
of carbon-based electrodes were considered as a voltammetric sensor platform for the
development of simultaneous determination procedures. The samples analyzed were
fixed-dose tablets, preferentially, but human fluids and water samples were also
analyzed. Voltammetric methods used for the simultaneous determination of
antihypertensive drugs revealed very sensitive approaches reaching limits of detection
in the micro-and nanomolar levels with analysis lasting less than one minute and
consuming very low or even no organic solvents.
Keywords: Antihypertensives, Carbon-based electrodes, Electroanalytical methods, Modified electrode, Simultaneous determination.
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