Heme-oxygenase and Autophagy connected as a Cytoprotective Mechanism: Potential Therapeutic Target

Pp: 1-27 (27)

* (Excluding Mailing and Handling)

Heme-oxygenase (HO) is an enzyme that catalyzes the main step of heme

degradation generating anti-inflammatory end products with protective roles in

physiologic and pathological situations. The relevance of HO in inflammatory

conditions is well reported through pharmacological and/or genetic modulation,

pointing out its importance in several models of stress such as infection, inflammation,

and oxidative disturbance. Under the referred situations, another well-known protective

process triggered is autophagy, in which defective cytosolic components and organelles

are eliminated via lysosomes. Besides its role on organelles and macromolecules

recycling, autophagy also contributes to cellular homeostasis by generating the

functional blocks required for anabolic reactions. Recently, different studies have

demonstrated a link between HO activity and autophagy activation. In this chapter, we

would like to draw the reader's attention to the interconnection between HO and

autophagy regarding stress response mechanisms, highlighting its importance in

homeostasis maintenance that might be useful in the therapy of inflammatory diseases

in the future.

Keywords: Autophagy, Bilirubin and biliverdin, Carbon monoxide, Curcumin, Cytoprotection, Heme, Heme-oxygenase, HO-therapy, Inflammation, Iron, Macroautophagy, Rapamycin, Reactive oxygen species, Resveratrol.

Cite as

Current Drug Safety

Inflammation & Allergy - Drug Targets (Discontinued)

Recent Patents on Anti-Infective Drug Discovery

Current Drug Discovery Technologies

Current Drug Targets - Inflammation & Allergy

Current Bioactive Compounds

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Anti-Cancer Agents in Medicinal Chemistry

Current Drug Targets

Letters in Drug Design & Discovery

A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems

Advances in Cancer Drug Targets

Angiogenesis & Therapeutic Targets In Cancer

Anti-Angiogenesis Drug Discovery and Development

DOI https://doi.org/10.2174/9789815036879122110003	Print ISSN 1574-0889
Publisher Name Bentham Science Publisher	Online ISSN 2212-1064

Frontiers in Drug Design and Discovery