Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach

Cancer is a multifactorial disease that is often asymptomatic and is thus

detected at an advanced stage. Late detection and resistance to treatment are two of the

major reasons for poor prognosis. The inherent limitations of conventional tools in

evaluating therapeutic responses, raise the need to monitor such responses during

treatment. Raman spectroscopy is a rapid, label-free, minimally invasive optical

vibrational spectroscopy technique that has been widely employed for cancer detection.

There is also significant literature on its applications in intraoperative surgical margin

assessment, chemotherapeutic drug monitoring, and prediction of radiation response.

However, most books and reviews focus on the diagnostic and screening applications

of Raman spectroscopy. This chapter describes the role of Raman spectroscopy in the

therapeutic monitoring of cancers and discusses its prospective applications. The

present work provides a brief introduction to the basic principles of Raman

spectroscopy, concise information on cancer aetiology, pathogenesis, diagnosis and

therapeutics, and applications of Raman spectroscopy in the therapeutic monitoring of

cancers. The role of Raman spectroscopy in monitoring conventional treatment

modalities such as surgery, radiotherapy, and chemotherapy, along with novel

treatment approaches such as immunotherapy and cold atmospheric plasma therapy, is

discussed in detail. The chapter concludes with a brief introduction to the emerging

field of Raman spectroscopy and artificial intelligence.

Keywords: Artificial Intelligence, Cancer, Cancer Field Effects, Cancer Therapy, Chemoresistance, Chemotherapy, Cold Atmospheric Plasma Therapy, Immunotherapy, Radioresistance, Radiotherapy, Raman Spectroscopy, Recurrence Prediction, Surgery, Surgical Margin, Therapeutic Drug Monitoring.

Cite as

Current Chinese Chemistry

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Anti-Cancer Agents in Medicinal Chemistry

Current Chinese Science

A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth

Advances in Anticancer Agents in Medicinal Chemistry

Advances in Combinatorial Chemistry & High Throughput Screening

Advances in Mathematical Chemistry and Applications

Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)

Advances in Organic Synthesis

DOI https://doi.org/10.2174/9789815036930122050007	Print ISSN 2542-5617
Publisher Name Bentham Science Publisher	Online ISSN 2542-5625

Recent Advances in Analytical Techniques