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Surface Enhanced Raman Spectroscopy: Biosensing and Diagnostic Technique for Healthcare Applications

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From Cells to Clinic - Direct Biomolecule Quantification of Clinically Relevant Biomolecules

Author(s): Swati Jain, Harsimran Singh Bindra and Sruti Chattopadhyay * .

Pp: 154-190 (37)

DOI: 10.2174/9789815039115121010009

* (Excluding Mailing and Handling)

Abstract

Translation of investigative cellular analysis into reliable clinical settings is
a challenge and surface enhanced Raman spectroscopic (SERS) technique has the
potential to move beyond laboratorial examinations. Quantitative and qualitative
measurement of cellular components and their properties is essential indicative of
healthy or disease state. Pre-emptive analysis of diseased state offers synchronization
with early diagnosis of certain medical conditions and is requisite for initiation of
therapeutic interventions. High sensitivity and capacity for multiplexing renders SERS
suitable for biochemical analysis for disease diagnosis a critical step towards
formulation of therapeutic regime. SERS assists in a deeper understanding of cellular
processes and its micro environment without disturbing and damaging the cellular
milieu in 3 dimensional (3D) set up without invading the tissues. Fabrication of novel
nanostructures with enhanced plasmonic effects has also propelled the growth of SERS
based analysis of cellular structure in normal and abnormal circumstances. Thus, SERS
is operating as diagnostic tool for in-vitro, ex-vivo and in-vivo investigations for
assessing onset of disease as well as prognosis of the therapy in hospitals and clinics.

Keywords: Continuous Glucose Monitoring, Neurotransmitters, Surfaceenhanced Spatially-offset Raman Spectroscopy (SESORS).

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