Abstract
Single-molecule detection (SMD) has shown to be a high-impact research field that could be developed based on nanoscale control with optical setups. In this way, different device and instrumental approaches could be implemented in biophotonic studies at SMD levels. For these reasons, varied designs of nanoplatforms, optical resonators, optical trapping, nano-patterned surfaces, and modified chemical surfaces are reviewed for SMD applications. In all these developments, signal transduction and enhancement led to the success of the targeted application. Therefore, we discuss here plasmonic [67] and enhanced plasmonic (EP) approaches, enhanced fluorescence signaling based on metal enhanced fluorescence (MEF) and plasmonic resonators, nanoantennas, and targeted molecular interactions by chemical modification of surfaces.
Keywords: Biophotonics, Molecular recognition, Nanophotonics, Optical resonator, Plasmonic nanoplatform, Single-molecule detection (SMD).
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