Nanoparticle Immunotherapy

Abstract

Immunostimulatory agents such as adjuvants, cytokines, and antibodies have a great potential for the treatment of disease conditions. However, their direct administration may lead to suboptimal pharmacokinetics, compromised targeting and vulnerability to biodegradation. To overcome these drawbacks, nanoparticles play a vital role and they improve the delivery mechanism of these therapeutic agents. The nanoparticle in conjugation elevates the bioavailability of the encapsulated payloads. In this study, we intended to discuss these immunostimulants when delivered by nanoparticles.

Keywords: Adjuvant, Antibody, Antigens, Breast cancer, Cytokines, Dendritic cells, Dextran nanoparticle, Gold nanoparticle, Immunostimulants, Immunosuppression, Inorganic nanoparticle, Lipid nanoparticle, Melanoma, Mesoporous silica nanoparticle, Microenvironment, Organic nanoparticle, OVA, PEG, PLGA, Polymeric nanoparticle, Toll like receptor.