Exercises in Organic Synthesis Based on Synthetic Drugs

Multicomponent Reaction (MCR)

Author(s): Marcus Vinícius Nora de Souza

Pp: 176-196 (21)

DOI: 10.2174/9789811487569120010009

* (Excluding Mailing and Handling)

Abstract

Multicomponent reaction (MCR) is a type of reaction based on a mixture of three or more compounds or reagents leading only to one or a major molecule being able to form complex molecules with a high degree of control of the stereogenic centers in only one step. This methodology is also a useful tool in medicinal chemistry to produce a diversity of compounds for biological evaluation. Due to its importance, the exercises below focus on this technique.


Keywords: Bioactive compounds, Chemical transformations, Combinatorial chemistry, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules, Multicomponent reaction (MCR), Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.

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