Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy

Lymphocytes play important roles in body defense for a few diseases, such as tumor diseases, autoimmune diseases, allergic inflammation. The genomic profiles with their analyses for body defense of lymphocytes have been applied to identify and verify disease-associated and disease-specific biomarkers. The genomic profiles of lymphocytes also can provide more information to understand their functions and roles in the development of tumor diseases, although genomic profiles from lymphocytes are still not completed for different tumor diseases. The chapter first reviews subtypes/functions and signaling/pathways of different lymphocytes and then introduce genomic profiles with their networks on these types of lymphocytes to highlight the genomic profiles of lymphocytes in tumor diseases. The genomic profiles are going to produce clinical potentials of precision medicine such as tumor prediction, tumor prevention, and prognostic estimation and personalized therapy of lymphocytes so that, here, we will more focus on the study of genomic expression and network of personalized immunotherapy because the profiles of gene expression with their network in lymphocytes start a new chance to develop personalized immunotherapy soon.

Keywords: B-cells, Genomic Expression Profiles, NK Cells, Network, Pathway, Personalized Immunotherapy, Precision Medicine, Single-Cell RNA-seq, T-Cells.