Design and Development of Bimetallic Enantioselective Salen Co Catalysts for the Hydrolytic Kinetic Resolution of Terminal Epoxides

Pp: 16-65 (50)

* (Excluding Mailing and Handling)

Abstract

The hydrolytic kinetic resolution of terminal epoxides catalyzed by the monometallic chiral salen Co complex follows the cooperative bimetallic mechanism and second order kinetic dependency on the catalyst. In this mechanism, one metal works as an active Lewis acid center for preferential activation of one enantiomer from a racemic substrate and the second metal center stimulates the incoming nucleophile. Mechanistically, rational design and development of bi- and multimetallic chiral complex centers within the sterically, electronically, and co-ordinatively accessible framework of chiral salen ligand provides improved activity and enantioselectivity relative to their corresponding monometallic catalysts. This chapter provides a survey of bimetallic chiral salen Co complexes used in the hydrolytic kinetic resolution of terminal epoxides to procure valuable chiral intermediates, useful for academic interest and in industrial applications.

Keywords: Asymmetric catalysis, Chiral salen Co complex, Kinetic resolutions, Terminal epoxides.

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