Current Advances in Breast Cancer Research: A Molecular Approach

Calcium Signaling in Breast Cancer: Current Perspective

Author(s): Manuraj Pandey, Akanksha Nigam and Rajendra Mehta

Pp: 278-304 (27)

DOI: 10.2174/9789811451447120010014

* (Excluding Mailing and Handling)

Abstract

Calcium (Ca2+) signaling plays an important role in every aspect of cellular physiology, including cell proliferation, cell death, and cell motility. In the cellular environment, calcium signaling is tightly regulated to achieve a specific cellular response. Dysregulation in cell proliferation and cell death are crucial events in cancer evolution. There are several reports which have established the central role of calcium signaling in acquiring the hallmarks of cancer. Calcium signaling has been shown to be linked with several proteins and pathways, which are involved in the progression and advancement of breast cancer, including RANK/RANKL signaling pathway, EGFR and CAMK signaling, Rap2B, ERK1/2 signaling, Ca2+ influx pathways, MCU proteins, PTHrP, calmodulin, PARP1, NFAT, calpain, mitogen-activated protein kinase (MAPK), calmodulin-dependent protein kinase II (CaMKII), epithelial-mesenchymal transition (EMT), phospholipase C (PLC), inositol 1,4,5-trisphosphate (IP3), vascular endothelial growth factor (VEGF), estrogen, and estrogen receptor. In the recent past, several studies presented good enough pieces of evidence suggesting Ca2+ channels and transporters as a potential therapeutic target of breast cancer treatment. Therefore, in light of previous knowledge, in this chapter, we will discuss the role of Ca2+ signaling in breast cancer and its therapeutic implication as to the current perspective of breast cancer treatment.


Keywords: Breast cancer, Ca2+ homeostasis, Ca2+ channels, Cancer therapy, Ca2+ channel blockers, Mammary gland, ORAI, PMCA, Store-operated Ca2+ entry, TRP.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59771045 and j.to_ip >=59771045 )) and ((j.from_date <= 1740736221 and j.to_date >= 1740736221 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13592) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59771045 and j.to_ip >=59771045 )) and ((j.from_date <= 1740736221 and j.to_date >= 1740736221 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13592) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59771045 and j.to_ip >=59771045 )) and ((j.from_date <= 1740736221 and j.to_date >= 1740736221 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13592)
      910μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2512 and `b`.`banner_from_date` <= 1740736221 and `b`.`banner_to_date` >= 1740736221 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      21.28msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2512
      • 3: 1740736221
      • 4: 1740736221
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='96658120bd34378e41f20c98fa5bf72b'
      8.53msalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:290
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    10Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        lYYSA1qJ2uYWAx5tUqntGIMFThHF3CVm3aAdDcs2
        uc_cart_id
        96658120bd34378e41f20c98fa5bf72b
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/13592" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/13592
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
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        session_attributes
        0 of 0
        array:5 [ "_token" => "lYYSA1qJ2uYWAx5tUqntGIMFThHF3CVm3aAdDcs2" "uc_cart_id" => "96658120bd34378e41f20c98fa5bf72b" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/13592" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 09:50:21GET/chapter/135921121912