Current Advances in Breast Cancer Research: A Molecular Approach

Oxidative Stress and Lifestyle-based Changes in Breast Cancer Progression

Author(s): Vipendra K. Singh and Pradeep K. Sharma

Pp: 208-235 (28)

DOI: 10.2174/9789811451447120010011

* (Excluding Mailing and Handling)

Abstract

Lifestyle-based changes such as diet, physical inactivity, smoking, and alcohol consumption are some key risk factors of breast cancer among women. Changes in the lifestyle disrupt redox homeostasis, particularly decreasing the ability of the body to detoxify harmful free radicals. Therefore, an imbalance between these finely tuned mechanisms results in the formation of excessive reactive oxygen species (ROS). These elevated levels of ROS may promote breast cancer development and progression. Over the centuries, the way of living has changed drastically worldwide, and several lifestyle factors have evolved as a threat and risk factor for cancer in humans. Most of these lifestyle factors, e.g., smoking, alcohol consumption, physical inactivity, poor nutrition, etc., have been associated with the rise in breast cancer incidences globally. A large number of accumulating evidence from clinical and epidemiological studies strongly suggest the link between lifestyle factors and the incidence of breast cancer in women. Some changes in lifestyles increase the risk of breast cancer in both premenopausal and postmenopausal women. However, the period between menarche to the birth of the first child is the most vulnerable phase in women's lives. Lifestyle factors drive carcinogenesis through various mechanisms. Among them, ROS-mediated oxidative damage plays a significant role in breast cancer development. Here, in this chapter, we have discussed the most relevant lifestyle factors associated with breast carcinogenesis in women. Also, we have discussed how these lifestyle factors modulate redox homeostasis to elicit oxidative damage-induced carcinogenesis. A better understanding of the association between lifestyle factors and breast cancer may enable us to identify critical factors that can play a significant role in breast carcinogenesis.


Keywords: Breast cancer, Diet, Lifestyle factors, Oxidative stress, Reactive oxygen species.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345378 and j.to_date >= 1740345378 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13589) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345378 and j.to_date >= 1740345378 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13589) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345378 and j.to_date >= 1740345378 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 13589)
      660μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2512 and `b`.`banner_from_date` <= 1740345378 and `b`.`banner_to_date` >= 1740345378 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.1msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2512
      • 3: 1740345378
      • 4: 1740345378
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='5b5fd92cd5a46b959489dfcf310a3b5e'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    5Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        yFL9Vgqjt5bZkvBBjaQ7G5Abt57mt71ycxqsn4cY
        uc_cart_id
        5b5fd92cd5a46b959489dfcf310a3b5e
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/13589" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/13589
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
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        response_headers
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        session_attributes
        0 of 0
        array:5 [ "_token" => "yFL9Vgqjt5bZkvBBjaQ7G5Abt57mt71ycxqsn4cY" "uc_cart_id" => "5b5fd92cd5a46b959489dfcf310a3b5e" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/13589" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:16:18GET/chapter/13589112197