Frontiers in Anti-Cancer Drug Discovery

Volume: 9

Pro-Apoptotic and Anti-Telomerase Activity of Naturally Occurring Compounds

Author(s): Mahendar Porika, Radhika Tippani and Nazneen Firdous

Pp: 193-233 (41)

DOI: 10.2174/9781681087016118090007

* (Excluding Mailing and Handling)

Abstract

A common hallmark of human cancers is the over expression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends and often directly correlated with the uncontrolled growth of cancer cells. Telomerase activity is present in 85-90% of all cancers, but absent in normal cells, which makes telomerase a good marker for cancer diagnosis and prognosis. Also, telomerase inhibition can be used as a novel anticancer therapy with reduced probability of toxicity than present antimalignancy drugs. However, current treatments used for cancer such as radiation, anti-hormonal therapy, surgery and chemotherapy using synthetic drugs, have been reported to produce various side effects. Therefore, it is crucial to reveal the beneficial effects of natural compounds with lesser side effects on normal cells and potential anticancer activity. In recent years, several natural molecules have been discovered so far that arrest proliferation of cancer cells by inhibiting telomerase. In this book chapter, we highlighted the effect of natural compounds on cancer cell proliferation, telomerase activity and their mechanism of action.


Keywords: Apoptosis, Cancer, Natural Compounds, Telomerase.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51461718 and j.to_ip >=51461718 )) and ((j.from_date <= 1740515043 and j.to_date >= 1740515043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12786) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51461718 and j.to_ip >=51461718 )) and ((j.from_date <= 1740515043 and j.to_date >= 1740515043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12786) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51461718 and j.to_ip >=51461718 )) and ((j.from_date <= 1740515043 and j.to_date >= 1740515043 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12786)
      600μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2632 and `b`.`banner_from_date` <= 1740515043 and `b`.`banner_to_date` >= 1740515043 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2632
      • 3: 1740515043
      • 4: 1740515043
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='db075c225a2f410e75c40b90ea2d3dc4'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    4Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        XSlyqzlTKrhWujXVIf8NOyTeofiN6uAN5iQKlPpL
        uc_cart_id
        db075c225a2f410e75c40b90ea2d3dc4
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/12786" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/12786
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 20:24:03 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJJci9PZzRGUE1jYWlSQ21ybUJ1VVE9PSIsInZhbHVlIjoiQjh6T0ppeldQRUhIY3c4QlphbjRxdXlxM1VuY2wvVVVSV25VSDVPdXE2aGFjQnFpTzdJNUpsZjZrYmJ4VW03a0RHTmpjN0g4Nm80aG5IVTBsditJMzIyWXFaMGF1R3MzcERFNTFlSzN5WWRiTmlEMzJEams5VVZSbUpuWFdqVlciLCJtYWMiOiI4NGI3Y2M3YjlkMWM3MTQwMjFhZGE0ODU2NGZjY2Y1NjhhZjg4YjhmM2IxMTc3NTRkMTY2ZmMyYWU5YmQxNGViIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 08:24:03 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkJJci9PZzRGUE1jYWlSQ21ybUJ1VVE9PSIsInZhbHVlIjoiQjh6T0ppeldQRUhIY3c4QlphbjRxdXlxM1VuY2wvVVVSV25VSDVPdXE2aGFjQnFpTzdJNUpsZjZrYmJ4VW03a0RHTmpjN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkwyVjN3eVdHWmZvUURVa2NoZzRIZUE9PSIsInZhbHVlIjoiMHFPTU9iK0Z2cDR0c0UxdUpjbXFDWE1BSzY0UmVmR25zSjRFcFdXbDRLMnpVTGxMa3JBd2dyb1JIdEtPVUpsRC9IUURKbDFTdXNLVU5ScjRLaEdsNFJqNTIwQ25CWEpDSlZEaGtVSVZadjc1eGFJL28yNnhiOHpxZWR5aE4rVU0iLCJtYWMiOiJhOGViNGYxOTRlOTAxNzBjOGYzZjI4Zjk0MmM4ODAyZjM0ZGM1ODNlOTBmMjQyMTdmMGNkZjhiNzQ3ZGY5N2U3IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IkwyVjN3eVdHWmZvUURVa2NoZzRIZUE9PSIsInZhbHVlIjoiMHFPTU9iK0Z2cDR0c0UxdUpjbXFDWE1BSzY0UmVmR25zSjRFcFdXbDRLMnpVTGxMa3JBd2dyb1J" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkJJci9PZzRGUE1jYWlSQ21ybUJ1VVE9PSIsInZhbHVlIjoiQjh6T0ppeldQRUhIY3c4QlphbjRxdXlxM1VuY2wvVVVSV25VSDVPdXE2aGFjQnFpTzdJNUpsZjZrYmJ4VW03a0RHTmpjN0g4Nm80aG5IVTBsditJMzIyWXFaMGF1R3MzcERFNTFlSzN5WWRiTmlEMzJEams5VVZSbUpuWFdqVlciLCJtYWMiOiI4NGI3Y2M3YjlkMWM3MTQwMjFhZGE0ODU2NGZjY2Y1NjhhZjg4YjhmM2IxMTc3NTRkMTY2ZmMyYWU5YmQxNGViIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 08:24:03 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkJJci9PZzRGUE1jYWlSQ21ybUJ1VVE9PSIsInZhbHVlIjoiQjh6T0ppeldQRUhIY3c4QlphbjRxdXlxM1VuY2wvVVVSV25VSDVPdXE2aGFjQnFpTzdJNUpsZjZrYmJ4VW03a0RHTmpjN" 1 => "alphaeurekaselectnet_session=eyJpdiI6IkwyVjN3eVdHWmZvUURVa2NoZzRIZUE9PSIsInZhbHVlIjoiMHFPTU9iK0Z2cDR0c0UxdUpjbXFDWE1BSzY0UmVmR25zSjRFcFdXbDRLMnpVTGxMa3JBd2dyb1JIdEtPVUpsRC9IUURKbDFTdXNLVU5ScjRLaEdsNFJqNTIwQ25CWEpDSlZEaGtVSVZadjc1eGFJL28yNnhiOHpxZWR5aE4rVU0iLCJtYWMiOiJhOGViNGYxOTRlOTAxNzBjOGYzZjI4Zjk0MmM4ODAyZjM0ZGM1ODNlOTBmMjQyMTdmMGNkZjhiNzQ3ZGY5N2U3IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IkwyVjN3eVdHWmZvUURVa2NoZzRIZUE9PSIsInZhbHVlIjoiMHFPTU9iK0Z2cDR0c0UxdUpjbXFDWE1BSzY0UmVmR25zSjRFcFdXbDRLMnpVTGxMa3JBd2dyb1J" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "XSlyqzlTKrhWujXVIf8NOyTeofiN6uAN5iQKlPpL" "uc_cart_id" => "db075c225a2f410e75c40b90ea2d3dc4" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/12786" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 20:24:03GET/chapter/12786112196