Frontiers in Anti-Cancer Drug Discovery

Volume: 9

Selective Anti-Cancer Drugs against Multi-drug Resistance

Author(s): Tijana Stankovic, Ana Podolski-Renic, Jelena Dinic and Milica Pesic

Pp: 114-192 (79)

DOI: 10.2174/9781681087016118090006

* (Excluding Mailing and Handling)

Abstract

Collateral sensitivity (CS) is a phenomenon in which development of multidrug resistance (MDR) in cancer cells confers higher sensitivity to other drugs compared to parental cells. This means that along with advantages, MDR cancer cells may adopt certain weaknesses. Therefore, MDR phenotype became a target for the development of new drugs, termed MDR-selective compounds. These compounds may exploit the overexpression of ATP Binding Cassette (ABC) transporters, directly acting on transporters’ ATPase function or indirectly acting on mechanisms independent of transporters activity. Herein, we review the current findings regarding the specific mechanisms of MDR selective drugs, their potential use in combination with other drugs or chemotherapeutics and perspectives in finding new anti-cancer options for MDR treatment.


Keywords: Autophagy, Anti-Cancer Agents, ATP-Binding Cassette (ABC) Transporters, ABC Transporters’ Inhibitors, Antioxidant Capacity, Collateral Sensitivity, Energetic Sensitivity, Glutathione Depletion, Microtubule Composition, Multi-drug Resistance, Plasma Membrane Symmetry.

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      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
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      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
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      • 17. app/Http/Controllers/ChapterController.php:1434
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      • 16. app/Models/Subject.php:255
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      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      • 15. app/Http/Controllers/ChapterController.php:1435
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      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1465
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
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      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ChapterController.php:1478
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316548017 and j.to_ip >=316548017 )) and ((j.from_date <= 1740457218 and j.to_date >= 1740457218 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12785) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316548017 and j.to_ip >=316548017 )) and ((j.from_date <= 1740457218 and j.to_date >= 1740457218 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12785) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316548017 and j.to_ip >=316548017 )) and ((j.from_date <= 1740457218 and j.to_date >= 1740457218 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 12785)
      890μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2632 and `b`.`banner_from_date` <= 1740457218 and `b`.`banner_to_date` >= 1740457218 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.44msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2632
      • 3: 1740457218
      • 4: 1740457218
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='615a4392a9456a3342f94f10a4fa7cf7'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    11Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        UD9cbXUpnmq6t51iaXbdQXnE01brjCgGgrXNdzTr
        uc_cart_id
        615a4392a9456a3342f94f10a4fa7cf7
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/12785" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/12785
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 04:20:18 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5QakFjTDBnUStrTmJFVjZVL0s3elE9PSIsInZhbHVlIjoiSGJJa2w1dFk0emRoSlpleERwbkg5SDE5VUo4US9MbE9GVmc1ODdQN2dWeFNOVU4zanVKd3d6WFBodlFZWXlac1lZTi9oVWNJcUJONExRaUdDTitOMGRMNjJRUVdXdUg0UmRnVkJaZ1hzMU4yR2xhdC94MWI0R2ZLRzhsbnZsNk0iLCJtYWMiOiI4MDBmZDgwZGNhYjVkY2MxZGVlY2FhNDQ2NTc1Y2NiZTAxNzliNWQyNGFiMTdiNTk1ZGFiMmMzNDMxMDc4NWQ3IiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 16:20:18 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ik5QakFjTDBnUStrTmJFVjZVL0s3elE9PSIsInZhbHVlIjoiSGJJa2w1dFk0emRoSlpleERwbkg5SDE5VUo4US9MbE9GVmc1ODdQN2dWeFNOVU4zanVKd3d6WFBodlFZWXlac1lZTi9oV" 1 => "alphaeurekaselectnet_session=eyJpdiI6InUrRmFWd3VORElmZzNweHVPZys0c3c9PSIsInZhbHVlIjoiYS85Z0dCODRoRHJWQnNUT0p2QjJrcWthUXYwNW9BdnZ2V2pDb2I1a2VFdGhqaC83M04zZm5KM0hFRFFpbmpHenYvNmkvRjhFc1drdlYvWGJ2ZW94QTk3UEZJSG1MNVFMLzRFVExkWktHQk5Gako0S3BFMmxPR0g0cXVzZUtzWHEiLCJtYWMiOiJiNGNmODQ2NDJhYmZlMzM5MzcyOGNhYjg0MzUwZTg4MTU0MjA0YTgzMzI5NTRlOTVlNzUyMDE5NWNlZTUyODkwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InUrRmFWd3VORElmZzNweHVPZys0c3c9PSIsInZhbHVlIjoiYS85Z0dCODRoRHJWQnNUT0p2QjJrcWthUXYwNW9BdnZ2V2pDb2I1a2VFdGhqaC83M04zZm5KM0h" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5QakFjTDBnUStrTmJFVjZVL0s3elE9PSIsInZhbHVlIjoiSGJJa2w1dFk0emRoSlpleERwbkg5SDE5VUo4US9MbE9GVmc1ODdQN2dWeFNOVU4zanVKd3d6WFBodlFZWXlac1lZTi9oVWNJcUJONExRaUdDTitOMGRMNjJRUVdXdUg0UmRnVkJaZ1hzMU4yR2xhdC94MWI0R2ZLRzhsbnZsNk0iLCJtYWMiOiI4MDBmZDgwZGNhYjVkY2MxZGVlY2FhNDQ2NTc1Y2NiZTAxNzliNWQyNGFiMTdiNTk1ZGFiMmMzNDMxMDc4NWQ3IiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 16:20:18 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ik5QakFjTDBnUStrTmJFVjZVL0s3elE9PSIsInZhbHVlIjoiSGJJa2w1dFk0emRoSlpleERwbkg5SDE5VUo4US9MbE9GVmc1ODdQN2dWeFNOVU4zanVKd3d6WFBodlFZWXlac1lZTi9oV" 1 => "alphaeurekaselectnet_session=eyJpdiI6InUrRmFWd3VORElmZzNweHVPZys0c3c9PSIsInZhbHVlIjoiYS85Z0dCODRoRHJWQnNUT0p2QjJrcWthUXYwNW9BdnZ2V2pDb2I1a2VFdGhqaC83M04zZm5KM0hFRFFpbmpHenYvNmkvRjhFc1drdlYvWGJ2ZW94QTk3UEZJSG1MNVFMLzRFVExkWktHQk5Gako0S3BFMmxPR0g0cXVzZUtzWHEiLCJtYWMiOiJiNGNmODQ2NDJhYmZlMzM5MzcyOGNhYjg0MzUwZTg4MTU0MjA0YTgzMzI5NTRlOTVlNzUyMDE5NWNlZTUyODkwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InUrRmFWd3VORElmZzNweHVPZys0c3c9PSIsInZhbHVlIjoiYS85Z0dCODRoRHJWQnNUT0p2QjJrcWthUXYwNW9BdnZ2V2pDb2I1a2VFdGhqaC83M04zZm5KM0h" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "UD9cbXUpnmq6t51iaXbdQXnE01brjCgGgrXNdzTr" "uc_cart_id" => "615a4392a9456a3342f94f10a4fa7cf7" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/12785" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 04:20:18GET/chapter/127851121913