Tropical Diseases: An Overview of Major Diseases Occurring in the Americas

In Silico Approaches Against Trypanosomatids

Author(s): Marcelo Zaldini Hernandes, Klaus Ribeiro Cavalcante, Rafael Freitas e Silva and Antonio Mauro Rezende

Pp: 51-87 (37)

DOI: 10.2174/9781681085876117010005

* (Excluding Mailing and Handling)

Abstract

Trypanosomatids parasites are causative agents of important neglected tropical diseases, such as leishmaniasis and Chagas disease. In the absence of an effective and safe vaccine, the main strategies currently available for the control of these diseases are chemotherapy whit drugs limited by their cost, toxicity, long time of treatment, and by emergence of resistant parasites. Therefore, in silico methods have arisen in the last years as powerful tools to optimize the search for new drugs and targets and for potential antigens for vaccines. In this context, the aim of this chapter is to provide the reader with important tools in use for drug design, particularly for molecular docking and epitope prediction for vaccines, in order to make useful to put this concepts and approaches in practice. All these tools should be applied in the fight against trypanosomatids.


Keywords: Drug design, Epitope, In silico, Molecular docking, Target, Trypanosomatids, Vaccine design.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59615104 and j.to_ip >=59615104 )) and ((j.from_date <= 1740496848 and j.to_date >= 1740496848 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11851) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59615104 and j.to_ip >=59615104 )) and ((j.from_date <= 1740496848 and j.to_date >= 1740496848 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11851) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59615104 and j.to_ip >=59615104 )) and ((j.from_date <= 1740496848 and j.to_date >= 1740496848 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11851)
      820μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2421 and `b`.`banner_from_date` <= 1740496848 and `b`.`banner_to_date` >= 1740496848 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.51msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2421
      • 3: 1740496848
      • 4: 1740496848
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='231553a3e557598a88dc6e1515da852e'
      290μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    7Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        2Mrd8sTe2PzrjZ9LxGRkeq2I7RuYMaHw3DVl07Tb
        uc_cart_id
        231553a3e557598a88dc6e1515da852e
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/11851" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/11851
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
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        response_headers
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        session_attributes
        0 of 0
        array:5 [ "_token" => "2Mrd8sTe2PzrjZ9LxGRkeq2I7RuYMaHw3DVl07Tb" "uc_cart_id" => "231553a3e557598a88dc6e1515da852e" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/11851" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 15:20:48GET/chapter/11851112199