Frontiers in Biomaterials

Volume: 5

Dental Tissue Engineering and Regeneration; Perspectives on Stem Cells, Bioregulators, and Porous Scaffolds

Author(s): Perihan Selcan Gungor-Ozkerim and Abdulmonem Alshihri

Pp: 36-76 (41)

DOI: 10.2174/9781681085784117050005

* (Excluding Mailing and Handling)

Abstract

Dental/orofacial tissue engineering is an emerging field that offers alternative solutions for dental problems resulting from pathologies such as caries, trauma, periodontal disease and others. Various stem cell types such as bone marrow stem cells (BMSCs) and adipose tissue-derived stem cells (ADSCs) can be employed as cell sources for dental tissue repair. In particular, dental tissue-derived stem cells such as dental pulp stem cells (DPSCS) and dental follicle stem cells (DFSCs) can be utilized due to their favorable origin and properties. On the other hand, natural and synthetic polymers are used to fabricate 3D dental tissue scaffolds to support cellular activities. Several bioregulators such as cytokines and growth factors can also be incorporated to induce cells interaction and cell-scaffold integration. The literature on the regeneration of dental tissues via tissue engineering principles presents numerous results that are superior to the traditional methods, which are vital for advancing dental therapy. Herein, the types, properties, and applications of dental stem cells (DSCs) were reviewed, as well as the tissue engineering and regeneration strategies for different types of dental tissues.


Keywords: 3D scaffolds, Alveolar bone, Dental pulp, Dental tissue engineering, Dental follicle, Growth factors, Intrabony defect, Periodontium, Periodontal ligament, Stem cells, Tissue regeneration.

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      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1518
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740457892 and j.to_date >= 1740457892 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11038) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740457892 and j.to_date >= 1740457892 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11038) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"chapter" as access_level, j.chapter_id from `user_access_chapter_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59620938 and j.to_ip >=59620938 )) and ((j.from_date <= 1740457892 and j.to_date >= 1740457892 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.chapter_id = 11038)
      760μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ChapterController.php:1549
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 2266 and `b`.`banner_from_date` <= 1740457892 and `b`.`banner_to_date` >= 1740457892 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.1msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 2266
      • 3: 1740457892
      • 4: 1740457892
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='bd942f4401cce2c0728125541ecb97e8'
      280μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Keywords
    11Keywords.php#?
    App\Models\Chapter
    1Chapter.php#?
    App\Models\Ebook
    1Ebook.php#?
        _token
        aSReeNcN7HBUdYFsNvHiIvJfKODCcjcShAUgsPrN
        uc_cart_id
        bd942f4401cce2c0728125541ecb97e8
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/11038" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /chapter/11038
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
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        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 04:31:32 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImxucjJnUlFVbFZaTUNLbTUwWGM2ZkE9PSIsInZhbHVlIjoiZWlHZmY4a3JHZUs1NmhkcElSRE1vTHZWYUNBOFRnZUh5RVVZNTh2ei9kaUVsN09WZ3BYSVh4KzZGWUJ5YVRsNFlWTzNTOE1Ha05ub05XM3IxMkZDcTVSVUNzUWxHZG5kZEJJclI4enJ1WW9jN2dLeHJjRUNaVkNnZXk5cHFoN2ciLCJtYWMiOiIzZTM1MGYyZjAwNDkxZDdkMWIwYzkyZTk0ZGU2MmU2NmEyOWQ4ZWFiNzI1YWZjYjZmZjhmMzUzMDU4MDE3NzMzIiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 16:31:32 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImxucjJnUlFVbFZaTUNLbTUwWGM2ZkE9PSIsInZhbHVlIjoiZWlHZmY4a3JHZUs1NmhkcElSRE1vTHZWYUNBOFRnZUh5RVVZNTh2ei9kaUVsN09WZ3BYSVh4KzZGWUJ5YVRsNFlWTzNTO" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZIaWtLVk1zU3hnL2tVL2EvQzdHaVE9PSIsInZhbHVlIjoiRXU1aThTL0VYeFFCRDRScXM3QU5GeXRFdElxVFV6ZnNLMXhWdWhtRUlsWmVtQ0VKL25kSFQ5WlY5aFhQajhaU2g1WUd5STE2UkNJTU1Hc1ZIMFNlb2VsZXcwRk15VmpaR2pycDQydjZ2RW1zb3YxRUloNjUwOTlwUC9tZDJBSDYiLCJtYWMiOiJlNDUzNDk5MGIyYTY1MDE2NmUyNGYzNzEwZTM0MzZjMzVhOGE2M2Q4MmE5NTdmM2VhM2Y2MWIxYjFlOTBlMDEwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjZIaWtLVk1zU3hnL2tVL2EvQzdHaVE9PSIsInZhbHVlIjoiRXU1aThTL0VYeFFCRDRScXM3QU5GeXRFdElxVFV6ZnNLMXhWdWhtRUlsWmVtQ0VKL25kSFQ5WlY" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImxucjJnUlFVbFZaTUNLbTUwWGM2ZkE9PSIsInZhbHVlIjoiZWlHZmY4a3JHZUs1NmhkcElSRE1vTHZWYUNBOFRnZUh5RVVZNTh2ei9kaUVsN09WZ3BYSVh4KzZGWUJ5YVRsNFlWTzNTOE1Ha05ub05XM3IxMkZDcTVSVUNzUWxHZG5kZEJJclI4enJ1WW9jN2dLeHJjRUNaVkNnZXk5cHFoN2ciLCJtYWMiOiIzZTM1MGYyZjAwNDkxZDdkMWIwYzkyZTk0ZGU2MmU2NmEyOWQ4ZWFiNzI1YWZjYjZmZjhmMzUzMDU4MDE3NzMzIiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 16:31:32 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImxucjJnUlFVbFZaTUNLbTUwWGM2ZkE9PSIsInZhbHVlIjoiZWlHZmY4a3JHZUs1NmhkcElSRE1vTHZWYUNBOFRnZUh5RVVZNTh2ei9kaUVsN09WZ3BYSVh4KzZGWUJ5YVRsNFlWTzNTO" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZIaWtLVk1zU3hnL2tVL2EvQzdHaVE9PSIsInZhbHVlIjoiRXU1aThTL0VYeFFCRDRScXM3QU5GeXRFdElxVFV6ZnNLMXhWdWhtRUlsWmVtQ0VKL25kSFQ5WlY5aFhQajhaU2g1WUd5STE2UkNJTU1Hc1ZIMFNlb2VsZXcwRk15VmpaR2pycDQydjZ2RW1zb3YxRUloNjUwOTlwUC9tZDJBSDYiLCJtYWMiOiJlNDUzNDk5MGIyYTY1MDE2NmUyNGYzNzEwZTM0MzZjMzVhOGE2M2Q4MmE5NTdmM2VhM2Y2MWIxYjFlOTBlMDEwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjZIaWtLVk1zU3hnL2tVL2EvQzdHaVE9PSIsInZhbHVlIjoiRXU1aThTL0VYeFFCRDRScXM3QU5GeXRFdElxVFV6ZnNLMXhWdWhtRUlsWmVtQ0VKL25kSFQ5WlY" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "aSReeNcN7HBUdYFsNvHiIvJfKODCcjcShAUgsPrN" "uc_cart_id" => "bd942f4401cce2c0728125541ecb97e8" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/chapter/11038" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 04:31:32GET/chapter/110381121913