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Review Article

登革热研究的多角度回顾

卷 20, 期 15, 2019

页: [1550 - 1562] 页: 13

弟呕挨: 10.2174/1389450120666190724145937

价格: $65

摘要

登革热是由雌性伊蚊传播的一种名为黄病毒科病毒的病毒引起的。如今，这在世界卫生组织的非洲，美洲，东地中海，东南亚和西太平洋地区的100多个国家中很普遍。典型登革热的治疗重点在于缓解症状和体征。木瓜番木瓜是一种非常常见的植物，其叶提取物用于治疗这种疾病。尽管对登革热进行了广泛的研究，但直到2016年仍没有单一疫苗或抗病毒药物（由赛诺菲巴斯德生产的DENV四价登革热疫苗治疗登革热的部分有效的嵌合黄热病毒）。这篇综述重点介绍了登革热的现状，并解释了通过结构活性关系研究发现的天然化学部分（如蛋氨酸，脯氨酸苯胺，四肽醛）的重要性。此外，我们还审查了目前在临床试验中有可能解决这些问题的候选药物。这篇综述概述了过去20年中的重要专利。已对可能在治愈登革热中起主要作用的不同可能靶蛋白进行了深入的蛋白质数据库分析。

关键词: 登革热传播，结构蛋白，非结构蛋白，蛋白数据库，计算机工作，临床研究，专利。

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