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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Role and Function of Adenosine and its Receptors in Inflammation, Neuroinflammation, IBS, Autoimmune Inflammatory Disorders, Rheumatoid Arthritis and Psoriasis

Author(s): Ashok K. Shakya*, Rajashri R. Naik, Ihab M. ALMASRI and Avneet Kaur

Volume 25, Issue 26, 2019

Page: [2875 - 2891] Pages: 17

DOI: 10.2174/1381612825666190716145206

Price: $65

Abstract

The physiological effects of endogenous adenosine on various organ systems are very complex and numerous which are elicited upon activation of any of the four G-protein-coupled receptors (GPCRs) denoted as A1, A2A, A2B and A3 adenosine receptors (ARs). Several fused heterocyclic and non-xanthine derivatives are reported as a possible target for these receptors due to physiological problems and lack of selectivity of xanthine derivatives. In the present review, we have discussed the development of various new chemical entities as a target for these receptors. In addition, compounds acting on adenosine receptors can be utilized in treating diseases like inflammation, neuroinflammation, autoimmune and related diseases.

Keywords: A1, A2A, A2B and A3, adenosine receptors, GPCR, inflammation, irritable bowel syndrome, neuroinflammation.

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