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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Free Radical Scavenging and Some Pharmaceutical Utilities of Nanoparticles in the Recent Scenario

Author(s): Xavier-Ravi Baskaran, Antony-Varuvel G. Vigila, Kilimas Rajan, Shouzhou Zhang and Wenbo Liao*

Volume 25, Issue 24, 2019

Page: [2677 - 2693] Pages: 17

DOI: 10.2174/1381612825666190716110330

Price: $65

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Abstract

Background: Nanopharmaceuticals have rapidly emerged as a means to cure several diseases. There are numerous reports describing the development and application of nanopharmaceuticals. Here, we discussed nanoparticle synthesis and the mechanisms to scavenge free radicals. We also discuss their major properties and list several commercially available nanomedicines.

Results: Reactive oxygen and hydrogen species are formed during normal metabolism, and excessive reactive species can damage proteins, lipids, and DNA and cause disease. Plant- and microbe-based nanoparticles, which can protect tissues from free radical damage, have recently gained research momentum because they are inexpensive and safe.

Conclusion: Synthetic and biocompatible nanoparticles exhibit antioxidant, antidiabetic, anti-inflammatory, and anticancer properties, which can be used to treat several diseases. Further studies are needed to investigate their sizes, dose-dependent activities, and mechanisms of action.

Keywords: Antioxidant, anticancer, DPPH, free radicals, reactive oxygen species, silver nanoparticles

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