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Research Article

FAM13A、PHLDB1和CYP24A1多态性在乳腺癌风险中的作用

卷 19, 期 8, 2019

页: [579 - 588] 页: 10

弟呕挨: 10.2174/1566524019666190619125109

价格: $65

摘要

背景：单核苷酸多态性(SNPs)是乳腺癌易感性的重要指标. 目的：探讨中国汉族人群FAM13A、PHLDB 1和CYP24A1基因SNP与乳腺癌发病的关系。 方法：对379例女性乳腺癌患者和407例女性健康对照者进行病例对照研究。用Agena MassARRAY平台对3个SNP进行了基因分型使用χ2检验比较病例组和对照组之间的多态性等位基因和基因型频率。 遗传模型分析通过使用逻辑回归计算比值比（OR）和95％置信区间（CI）来评估SNP与乳腺癌风险之间的关联。 RegulomeDB和HaploReg数据库用于计算多态性的可能的功能效果。 结果：总体分析结果表明，rs4809957与乳腺癌风险增加相关（等位基因A：OR = 1.27，95％CI：1.03-1.55，p = 0.024； AA vs. GG：OR = 1.80，95％CI： 1.15–2.82，p = 0.010；隐性模型：OR = 1.70，95％CI：1.12-2.58，p = 0.012）； 在隐性模型中发现rs1059122与降低乳腺癌风险有关（OR = 0.71，95％CI：0.51-0.98，p = 0.039）。 分层分析发现三个SNP（rs1059122，rs17748和rs4809957）与乳腺癌风险之间存在显着关联。 结论：我们的结果表明，rs1059122（FAM13A），rs17748（PHLDB1）和rs4809957（CYP24A1）可能对中国汉族人群的乳腺癌易感性有贡献。 需要进一步的大样本研究来证实我们的发现，还需要进行功能研究以探索其在乳腺癌发展中的作用。

关键词: 乳腺癌，FAM13A，PHLDB1，CYP24A1，单核苷酸多态性，癌症。

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