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Review Article

PPARγ：超越糖尿病及其天然激动的疾病的潜在治疗靶点

卷 20, 期 12, 2019

页: [1281 - 1294] 页: 14

弟呕挨: 10.2174/1389450120666190527115538

价格: $65

摘要

在建立PPARγ作为糖尿病的治疗靶标方面已经观察到了强烈的研究兴趣。然而，PPARγ也正在成为除2型糖尿病之外的各种疾病状态的重要治疗靶标，如神经退行性疾病，癌症，脊髓损伤，哮喘和心血管疾病。此外，格列酮类，合成的噻唑烷二酮类，也称为胰岛素增敏剂，是大量研究的PPARγ激动剂，也是唯一被批准用于治疗2型糖尿病的激动剂。然而，它们会产生诸如液体潴留，肥胖，肝功能衰竭，骨折和心力衰竭等副作用;这限制了他们的临床应用。传统上使用的药用植物是用于开发成功药物的生物活性化合物的来源，并且已经建立了许多结构多样的天然分子作为PPARγ激动剂。与完全激动剂合成的噻唑烷二酮相比，这些天然部分激动剂导致较弱的PPARγ活化，副作用较小，但尚未彻底研究。通过饮食改变调节PPARγ活性，它们对机械活性的全面表征和阐明可能有助于抵抗疾病。我们的目的是回顾PPARγ对除糖尿病以外的疾病的治疗意义，并强调具有潜在PPARγ激动活性的天然分子。

关键词: PPARγ激动剂，天然产物，治疗剂，代谢综合征，癌症。

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图形摘要

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