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Review Article

考虑通过时间疗法治疗高血压的血压昼夜节律模式：有利或不良的方法

卷 20, 期 12, 2019

页: [1244 - 1254] 页: 11

弟呕挨: 10.2174/1389450120666190527114529

价格: $65

摘要

医学时间生物学涉及身体的节奏影响一个人的健康和疾病状态的方式。为了匹配身体节律，有意改变药物浓度以优化治疗结果并最小化尺寸效应，这种方法被称为Chronotherapeutics。一般而言，体内平衡的概念一直是治疗疾病的基础。在理解生物节律及其潜在机制方面，重要性不高。设计心血管药物是为了在规定剂量的整个24小时内达到恒定或接近恒定的效果。然而，在许多情况下，夜间和白天的药物需求是不一样的。身体节律可能对治疗结果产生深远影响。假设在早晨或晚上给药的药物具有相同的抗高血压作用是错误的方法。关于血压（BP），心率，激素分泌和血小板聚集的昼夜变化的大量文献记录是时间生物学影响的实例。在这项研究中，我们分析血压昼夜节律模式对各种抗高血压药的作用的影响，并研究时间疗法的观点 - 是否是一种富有成效的方法，并使其在治疗高血压中的实用性合理化。

关键词: 时间疗法，高血压，生物节律，抗高血压，体内平衡，时间生物学。

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