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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默氏病中的神经炎症：小胶质细胞，分子参与者和治疗选择

卷 16, 期 7, 2019

页: [659 - 674] 页: 16

弟呕挨: 10.2174/1567205016666190503151648

价格: $65

摘要

阿尔茨海默氏病是世界上最常见的痴呆症。 其病理学特征是β-淀粉样蛋白积累，细胞外老年斑和细胞内神经原纤维缠结的形成，以及神经元坏死和凋亡。 神经炎症已被广泛认为是参与AD发病机制的关键过程。 在这篇评论中，我们简要总结了小胶质细胞参与阿尔茨海默氏病神经炎症过程的过程。 还讨论了其在AD发作和进展中的作用。许多分子，包括白介素，肿瘤坏死因子α，趋化因子，炎症小体，都参与了与AD相关的神经炎症的复杂过程，在本综述中将对其进行选择性讨论。 在本文的结尾，从炎症相关的角度，我们讨论了一些潜在的治疗选择。

关键词: 阿尔茨海默病，神经炎症，小胶质细胞，β-淀粉样蛋白，痴呆，趋化酶。

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