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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

脑源性神经营养因子：神经退行性疾病与癌症之间的共同联系？

卷 16, 期 4, 2019

页: [344 - 352] 页: 9

弟呕挨: 10.2174/1567205016666190408123947

价格: $65

摘要

背景：癌症是由细胞过度增殖引起的常见疾病，神经退行性疾病是由于神经元退化引起的疾病。两者都可以被认为是由细胞周期事件的失调引起的疾病。最近的一项数据表明癌症与神经退行性疾病之间存在强烈的负相关关系。间接证据表明脑源性神经营养因子（BDNF）是这种关联中潜在的分子联系。 讨论：发现BDNF水平在许多神经退行性疾病中被下调，并且被发现在各种癌症中被上调。已发现阿尔茨海默氏症和帕金森氏病中较低水平的BDNF与认知和其他神经心理学损伤有关，而其较高水平与癌症患者的肿瘤生长和转移以及较差的存活率相关。 结论：在本综述中，我们提出BDNF水平的变化对于确定细胞病理生理过程和癌症或神经退行性疾病的发展至关重要。我们进一步提出可以调节BDNF表达的替代治疗策略，可以挽救或预防上述病理生理过程。通过动物研究检查这种联系的大型研究对于理解与健康和疾病的假定生化和分子联系是必不可少的。

关键词: BDNF，体内平衡，神经退行性疾病，BDNF / TrkB级联，替代疗法，阿尔茨海默病。

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