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Review Article

将对硼毒性的恐惧转变为含硼药物设计

卷 26, 期 26, 2019

页: [5005 - 5018] 页: 14

弟呕挨: 10.2174/0929867326666190327154954

价格: $65

摘要

背景：尽管历史上出于医学目的使用含硼化合物（BCC），但在20世纪报道的人类BCC毒性案例驱使我们迈向“硼回收”时期。幸运的是，仍将硼酸用于特定目的，发现具有生物学活性的天然BCC对治疗具有吸引力，以及引入一些新的BCC用于临床用途，重新激发了人们对研究这些BCC性质的兴趣。 方法：我们对书目数据库进行了结构化搜索，以查找有关硼毒性的科学同行评审研究文献，并将该信息与药物设计和开发中的BCC相关联。使用演绎定性内容分析方法，使用理论提纲来分析纳入研究的干预措施和发现。 结果：本次审查概述了时间表：硼在医学中的用途，有关某些BCC的毒理学特征，用于癌症和传染病治疗的某些BCC的药理特性以及BCC的已知特性的已知数据最近被引入临床试验，并确定它们的结构-活性关系以用于毒性和治疗用途。然后，我们将讨论利用一些毒理学数据的新方法，以确定有效且有效的预防和治疗BCC，同时限制其毒性作用的方法。 结论：硼毒性数据可策略性地用于含硼药物设计。

关键词: 硼，含硼化合物，结构-毒性关系，药物设计，毒理学，传染病治疗。

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