摘要
口腔癌（OC）是一个严重且日益严重的问题，对经济较发达国家的人们构成巨大负担。美国被诊断为OC的新病例预计从2016年的49,670人增加到2017年的49,750例，这一情况清楚地描述了这种情况。印度的情况更加令人担忧，报告了75,000至80,000例新病例每年，因此成为世界的OC首都。世界卫生组织专家工作组强调白斑，红斑，口腔扁平苔藓，口腔粘膜下纤维化，盘状红斑狼疮，遗传性疾病如先天性角化病和大疱性表皮炎是增加OC风险的诱发因素。烟草和酒精，遗传因素和人乳头瘤病毒的消费被指定为导致OC病因的因素。另一方面，OC的发病机制不仅涉及细胞凋亡，还涉及疼痛，炎症和氧化应激。尽管目前的治疗选择（手术，放疗和化疗），OC通常与继发性原发肿瘤的复发和形成相关，导致总体存活率较差（~50％）。基于纳米技术的药物递送系统作为癌症治疗剂的干预通常被视为技术人员的前沿。虽然有关纳米癌症治疗药物有用性的大量文献，但很少有产品正在进行中。然而，尽管有关纳米技术的大肆宣传，但很少有正在进行的试验。该综述讨论了用于治疗OC的纳米药物递送的当前和未来趋势。
关键词: 口腔癌，流行病学，发病机制，化疗，纳米技术，放射治疗。
图形摘要
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