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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

阿尔茨海默病在黑暗中的异常骶管入侵

卷 16, 期 4, 2019

页: [293 - 301] 页: 9

弟呕挨: 10.2174/1567205016666190311102130

价格: $65

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摘要

背景：分类为扫视入侵，在阿尔茨海默病（AD）的视觉固定（VF）期间观察到Square-Wave Jerks（SWJs）。然而，这种现象的病理意义仍不清楚。 目的：本研究分析了AD患者在没有VF的情况下睁眼的SWJs的特征。 方法：对15名AD患者和15名健康的年龄和性别匹配对照进行调查和比较。使用和不使用VF的Saccadic侵入被检测为SWJ并使用电子眼震图测量。 结果：对照组和AD组VF之间SWJs频率无显着差异，但在没有VF的情况下，AD组中SWJs显着高于对照组（p <0.01）。在对照组中，与没有VF相比，VF的SWJ频率显着更高。相反，没有VF，AD组的频率显着更高。此外，在AD组的SWJ频率和高阶函数（R> 0.55）之间观察到直接比例关系。 结论：无ADF的SWJs可能在AD中具有病理学意义。在健康个体中，SWJ由VF产生并且在没有VF的情况下被抑制。相反，在AD中，在没有VF的情况下产生SWJ而不是抑制SWJ。这些没有VF的特异性SWJ也似乎与高阶功能障碍相关，反映了AD相关的皮质损伤。这些发现表明，在AD中观察到的没有VF的病理性SWJs来自皮质损伤，并且可能构成高阶功能的重要标志物。

关键词: 阿尔茨海默病，眼球运动，眼跳入侵，方波混蛋，视觉固定，高阶功能，下顶叶小叶，额叶眼。

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