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Review Article

B7-H3靶向放射免疫治疗人类癌症

卷 27, 期 24, 2020

页: [4016 - 4038] 页: 23

弟呕挨: 10.2174/0929867326666190228120908

价格: $65

摘要

背景：靶向放射免疫疗法（RIT）是一种有吸引力的方法，可以选择性地将治疗性放射性核素定位在原发性和转移性肿瘤内的恶性细胞上，同时使正常组织免受放射线的影响。许多人类恶性肿瘤在肿瘤细胞表面表达B7-H3，而在大多数正常组织中的表达受到限制，因此B7-H3作为RIT的候选靶点。这篇综述概述了靶向RIT的一般原理，并讨论了在临床前或临床研究中使用放射性标记的B7-H3靶向抗体治疗RIT的出版物。 方法：使用包括“ B7-H3”，“放射免疫疗法”，“靶向”，“放射疗法”和“癌症”在内的术语组合，搜索包括PubMed，Scopus和Google Scholar在内的数据库，直至2018年6月。在筛选搜索结果的相关性之后，包括了十个出版物供讨论。 结果：迄今为止，针对B7-H3的RIT研究范围从抗体开发和评估人类癌症动物模型中的新型放射免疫偶联物（RIC）到人类的II / III期试验。大多数临床研究已将靶向B7-H3的RIC用于中枢神经系统恶性肿瘤的腔内RIT。这些研究的结果表明了高耐受性和良好的疗效，支持在更大的试验中进一步评估B7-H3靶向RIT。临床前针对B7-H3的RIT研究还显示出在各种实体恶性肿瘤中令人鼓舞的治疗结果。 结论：在过去15年中，针对B7-H3的RIT研究证明了临床开发的可行性，并支持在更广泛的人类恶性肿瘤中进行未来评估。值得探索的未来方向包括将B7-H3-靶向RIT与化学疗法或免疫疗法相结合的策略。

关键词: 靶向放射免疫治疗，B7-H3，癌症，mAb，放射治疗，放射免疫结合物(RIC)。

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