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Review Article

LncRNAs：在结直肠癌中潜在的新型预后和诊断生物标志物。

卷 27, 期 30, 2020

页: [5067 - 5077] 页: 11

弟呕挨: 10.2174/0929867326666190227230024

价格: $65

摘要

背景：长非编码RNA（lncRNA）是一种调节性RNA，在众多细胞途径中起关键作用。 已指定这组非编码RNA的异位表达与多种疾病有关。 此外，已经确认lncRNA在包括结直肠癌（CRC）的癌症的引发和发展中的作用。 目的：在本综述中，lncRNAs作为CRC中预后和诊断生物标志物的作用以及其对CRC形成的贡献的分子机制已得到解决。 结果：目前的研究表明CRC中各种lncRNA的异位表达。 与健康对照组相比，一些被认为是抑癌基因的lncRNA在大肠癌组织中被下调。 然而，一些具有致癌作用的基因被上调。 LncRNA通过多种分子机制（例如表观遗传学控制靶基因的表达，与miRNA作为其海绵相互作用）来促进肿瘤的发展。 结论：已被认为是预后生物标志物的LncRNA可能为临床管理铺平道路，为CRC患者提供辅助治疗。

关键词: 生物标志物，结直肠癌（CRC），lncRNA，结直肠癌的诊断性生物标志物，CRC，支架因子。

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