摘要
背景：低密度脂蛋白（LDL）代谢的重要因素之一是LDL受体（LDLR）通过其结合并随后清除循环中来自LDL（LDL-C）的胆固醇的能力。前蛋白转化酶枯草杆菌蛋白酶样Kexin 9型（PCSK9）是一种新发现的丝氨酸蛋白酶，其破坏肝脏中的LDLR，从而控制血浆中的LDL水平。因此，抑制PCSK9介导的LDLR降解已成为降脂治疗的新靶标。 方法：我们回顾了目前对PCSK9结构和功能的理解及其对治疗高脂血症和动脉粥样硬化的意义。 结果：诸如针对PCSK9的单克隆抗体的新治疗可能是降低血浆LDL水平并因此预防动脉粥样硬化的有用药剂。 结论：PCSK9的作用机制尚未完全阐明。然而，针对PCSK9的治疗已显示出惊人的早期疗效，并有望改善无数高脂血症和动脉粥样硬化患者的生活。
关键词: 前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9），低密度脂蛋白胆固醇（LDL-C），LDL受体（LDLR），动脉粥样硬化，单克隆抗体，疫苗。
图形摘要
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