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General Review Article

当前抗炎治疗方法和分泌型磷脂酶A2抑制剂在新型抗炎药物设计中的潜力:2012 - 2018年综述

卷 27, 期 3, 2020

页: [477 - 497] 页: 21

弟呕挨: 10.2174/0929867326666190201120646

价格: $65

摘要

炎症过程是机体对损伤因子的一种自然自卫反应，其作用机制涉及一系列复杂的反应。然而，在某些情况下，这个过程会变成慢性的，对身体造成很大的伤害。因此，近年来，许多抗炎药物被开发出来，旨在降低机体内炎症介质的浓度，这是控制这些异常连锁反应的一种方法。传统抗炎药物的主要作用靶点是环氧化酶(COX)，但其使用存在多种副作用。因此，基于这些局限性，人们进行了许多研究，旨在创造具有新的作用机制的新药。从这个意义上说，磷脂酶A2 (PLA2)酶是最突出的。在所有现有的亚型中，分泌型PLA2是抑制剂开发的主要目标，因为许多研究已经证明这种酶参与各种炎症状态，如癌症、阿尔茨海默病和关节炎。最后，为了开发作为sPLA2抑制剂的抗炎药物，已经设计了许多分子。因此，本研究综述了炎症过程和介质、现有的抗炎药物，并简要介绍了PLA2酶，以及作为生产新抗炎药物可能靶点的最新的sPLA2抑制剂的多种结构阵列。

关键词: 磷脂酶A，炎症，新药设计，酶抑制剂，抗炎药，最新的专利。

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