[1]
Surh, Y.J. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res., 1999, 428(1-2), 305-327.
[2]
Grzanna, R.; Lindmark, L.; Frondoza, C.G. Ginger-an herbal medicinal product with broad anti-inflammatory actions. J. Med. Food, 2005, 8, 125-132.
[3]
Altman, R.D.; Marcussen, K.C. Effects of a ginger extract on knee
pain in patients with osteoarthritis. Arthritis Rheum., 2001, 44, 11-
2531-2538.
[4]
Ling, H.; Yang, H.; Tan, S.H.; Chui, W.K.; Chew, E.H. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-kappa B activation. Br. J. Pharmacol., 2010, 161, 1763-1777.
[5]
Tan, B.S.; Kang, O.; Mai, C.W.; Tiong, K.H.; Khoo, A.S.; Pichika, M.R.; Bradshaw, T.D.; Leong, C.O. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPAR gamma). Cancer Lett., 2013, 336, 127-139.
[8]
Liu, Y.; Whelan, R.J.; Pattnaik, B.R.; Ludwig, K.; Subudhi, E.; Rowland, H.; Claussen, N.; Zucker, N.; Uppal, S.; Kushner, D.M.; Felder, M.; Patankar, M.S.; Kapur, A. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PLoS One, 2012, 7(12), e53178.
[9]
Saha, A.; Blando, J.; Silver, E.; Beltran, L.; Sessler, J.; DiGiovanni, J. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-kappa B signaling. Cancer Prev. Res., 2014, 7, 627-638.
[10]
Tuntiwechapikul, W.; Taka, T.; Songsomboon, C.; Kaewtunjai, N.; Imsumran, A.; Makonkawkeyoon, L.; Pompimon, W.; Lee, T.R. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J. Med. Food, 2010, 13, 1347-1354.
[11]
Abdullah, S.; Abidin, S.A.Z.; Murad, N.A.; Makpol, S.; Ngah, W.Z.W.; Yusof, Y.A.M. Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr. J. Biochem. Res., 2010, 4, 134-142.
[12]
Johnstone, R.W.; Ruefli, A.A.; Lowe, S.W. Apoptosis: A link between cancer genetics and chemotherapy. Cell, 2002, 108, 153-164.
[13]
Elkady, A.I.; Osama, A.A.; Baeshen, N.A.; Rahmy, T.R. Differential Control of Growth, Apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale. J. Biomed. Biotechnol., 2012, 2012, 6143.
[14]
Folkman, J. Tumor angiogenesis: Therapeutic implications. N. Engl. J. Med., 1971, 285(21), 1182-1186.
[15]
Ferrara, N.; Kerbel, R.S. Angiogenesis as a therapeutic target. Nature, 2005, 438(7070), 967-974.
[16]
Folkman, J. Fighting cancer by attacking its blood supply. Sci. Am., 1996, 275(3), 150-154.
[18]
Rhode, J.; Fogoros, S.; Zick, S.; Wahl, H.; Griffith, K.A.; Huang, J.; Liu, J.R. Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complement. Altern. Med., 2007, 20(7), 44.
[19]
Weng, C.J.; Wu, C.F.; Huang, H.W.; Ho, C.T.; Yen, G.C. Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Mol. Nutr. Food Res., 2010, 54(11), 1618-1627.
[20]
Rahmani, A.H.; Al Shabrmi, F.M.; Allemailem, K.S.; Aly, S.M.; Khan, M.A. Implications of green tea and its constituents in the prevention of cancer via the modulation of cell signalling pathway. BioMed Res. Int., 2015, 2015, Article ID 925640.
[21]
Rahmani, A.H.; Aly, S.M.; Babiker, A.Y.; Srikar, S.; Khan, A.A. Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, antioxidant and anti-tumour activity. Int. J. Clin. Exp. Med., 2014, 7, 483-491.
[22]
Rahmani, A.H.; Al Zohairy, M.A.; Aly, S.M.; Khan, M.A. Curcumin: A potential candidate in prevention of cancer via modulation of molecular pathways. BioMed Res. Int., 2014, 2014, 761608.
[23]
Kikuzaki, H.; Nakatani, N. Cyclic diarylheptanoids from rhizomes of Zingiber officinale. Phytochemistry, 1996, 43, 273-277.
[24]
Danwilai, K.; Konmun, J.; Sripanidkulchai, B.; Subongkot, S. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: A pilot study. Cancer Manag. Res., 2017, 9, 11-18.
[25]
Bo, M.; Li, H.; Qu, W.; Yuan, H. anticancer effects of gingerol in retinoblastoma cancer cells (RB355 cell line) are mediated via apoptosis induction, cell cycle arrest and upregulation of PI3K/Akt signaling pathway. Med. Sci. Monit., 2018, 24, 1980-1987.
[26]
Rastogi, N.; Duggal, S.; Singh, S.K.; Porwal, K.; Srivastava, V.K.; Maurya, R.; Bhatt, M.L.; Mishra, D.P. Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells. Oncotarget, 2015, 6(41), 43310-43325.
[27]
Hsu, Y.L.; Chen, C.Y.; Lin, I.P.; Tsai, E.M.; Kuo, P.L.; Hou, M.F. 4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-kappaB/Snail on RKIP. J. Agric. Food Chem., 2012, 60, 852-861.
[28]
Rahmani, A.H.; Alzohairy, M.A.; Khan, M.A.; Aly, S.M. Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evid. Based Complement. Alternat. Med., 2014, 2014, 724658.
[29]
Pashaei-Asl, R.; Pashaei-Asl, F.; Gharabaghi, P.M.; Khodadadi, K.; Ebrahimi, M.; Ebrahimie, E.; Pashaiasl, M. The inhibitory effect of ginger extract on Ovarian cancer cell line; application of systems biology. Adv. Pharm. Bull., 2017, 7, 241-249.
[30]
Zhang, S.; Liu, Q.; Liu, Y.; Qiao, H. Zerumbone, a Southeast Asian ginger sesquiterpene, induced apoptosis of pancreatic carcinoma cells through p53 signaling pathway. Evid. Based Complement. Alternat. Med., 2012, 2012, 8.
[31]
Hollowood, K.; Macartney, J.C. Reduced apoptotic cell death in follicular lymphoma. J. Pathol., 1991, 163(4), 337-342.
[32]
Green, D.R. Apoptotic pathways: Paper wraps stone blunts scissors. Cell, 2000, 102(1), 1-4.
[34]
Wang, C.C.; Chen, L.G.; Lee, L.T.; Yang, L.L. Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In Vivo, 2003, 17(6), 641-645.
[35]
Lee, S.H.; Cekanova, M.B. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol. Carcinog., 2008, 47, 197-208.
[39]
Lee, S.H.; Cekanova, M.; Baek, S.J. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol. Carcinog., 2008, 47, 197-208.
[40]
Liu, Q.; Peng, Y-B.; Zhou, P.; Qi, L-W.; Zhang, M.; Gao, N.; Liu, E.H.; Li, P. 6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α. Mol. Cancer, 2013, 12(1), 135.
[41]
Hsu, Y.L.; Chen, C.Y.; Hou, M.F.; Tsai, E.M.; Jong, Y.J.; Hung, C.H.; Kuo, P.L. 6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells. Mol. Nutr. Food Res., 2010, 54, 1307-1317.
[42]
Chang, K.W.; Kuo, C.Y. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct., 2015, 6(10), 3334-3341.
[43]
Fan, J.; Yang, X.; Bi, Z. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol., 2015, 36(2), 1135-1141.
[45]
Li, Y.; Tran, V.H.; Koolaji, N.; Duke, C.; Roufogalis, B.D. (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+].. J. Pharm. Pharm. Sci., 2013, 16, 304-312.
[46]
Hashem, R.M.; Rashed, L.A.; Hassanin, K.M.A.; Hetta, M.H.; Ahmed, A.O. Effect of 6-gingerol on AMPK- NF-κB axis in high fat diet fed rats. Biomed. Pharmacother., 2017, 88, 293-301.
[47]
Li, Y.; Xu, B.; Xu, M.; Chen, D.; Xiong, Y.; Lian, M.; Sun, Y.; Tang, Z.; Wang, L.; Jiang, C.; Lin, Y. 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling. Pharmacol. Res., 2017, 119, 137-148.
[48]
Weng, C.J.; Chou, C.P.; Ho, C.T.; Yen, G.C. Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. Mol. Nutr. Food Res., 2012, 56(8), 1304-1314.
[50]
Witsch, E.; Sela, M.; Yarden, Y. Roles for growth factors in cancer progression. Physiology (Bethesda), 2010, 25, 85-101.
[52]
Hou, C.; Miao, Y.; Ji, H.; Wang, S.; Liang, G.; Zhang, Z.; Hong, W. 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression. An. Acad. Bras. Cienc., 2017, 89, 2707-2717.
[53]
Wang, D.; Jiang, Y.; Yang, X.; Wei, Q.; Wang, H. 6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses. Korean J. Physiol. Pharmacol., 2018, 22(6), 627-636.
[54]
Normanno, N.; de Luca, A.; Bianco, C.; Strizzi, L.; Mancino, M.; Maiello, M.R.; Carotenuto, A.; De Feo, G.; Caponigro, F.; Salomon, D.S. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene, 2006, 366, 2-16.
[56]
Geng, S.; Zheng, Y.; Meng, M. Gingerol reverses the cancer-promoting effect of capsaicin by increased TRPV1 level in a urethane-induced lung carcinogenic model. J. Agric. Food Chem., 2016, 64, 6203-6211.
[59]
Karin, M.; Cao, Y.; Greten, F.R.; Li, Z.W. NF-kappa B in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer, 2002, 2(4), 301-310.
[60]
Ling, H.; Yang, H.; Tan, S.H.; Chui, W.K.; Chew, E.H. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharm, 2010, 161, 1763-1777.
[62]
Zhou, L.; Qi, L.; Jiang, L.; Zhou, P.; Ma, J.; Xu, X.; Li, P. Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signalling by 6-shogaol. AAPS J., 2014, 16(2), 246-257.
[63]
Kim, S.M.; Kim, C.; Bae, H.; Lee, J.H.; Baek, S.H.; Nam, D.; Chung, W.S.; Shim, B.S.; Lee, S.G.; Kim, S.H.; Sethi, G.; Ahn, K.S. 6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways. Mol. Carcinog., 2015, 54(10), 1132-1146.
[64]
Luettig, J.; Rosenthal, R.; Lee, I.M.; Krug, S.M.; Schulzke, J.D. The ginger component 6-shogaol prevents TNF-alpha-induced barrier loss via inhibition of PI3K/Akt and NF-kappa B signaling. Mol. Nutr. Food Res., 2016, 60, 2576-2586.
[65]
Wang, Y.; Wang, S.; Song, R.; Cai, J.; Xu, J.; Tang, X.; Li, N. Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Int. J. Biol. Macromol., 2018, 123, 81-90.
[67]
Wu, J.J.; Omar, H.A.; Lee, Y.R.; Teng, Y.N.; Chen, P.S.; Chen, Y.C.; Huang, H.S.; Lee, K.H. Hung, J.H. 6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms. Eur. J. Pharmacol., 2015, 762, 449-458.
[68]
Liu, Q.; Peng, Y.B.; Qi, L.W.; Cheng, X.L.; Xu, X.J.; Liu, L.L.; Liu, E.H.; Li, P. The cytotoxicity mechanism of 6-shogaol-treated HeLa human cervical cancer cells revealed by label-free shotgun proteomics and bioinformatics analysis. Evid. Based Complement. Alternat. Med., 2012, 2012, 278652.
[69]
Gan, F.F.; Nagle, A.A.; Ang, X.; Ho, O.H.; Tan, S.H.; Yang, H.; Chui, W.K.; Chew, E.H. Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. Apoptosis, 2011, 16, 856-867.
[70]
Mangelsdorf, D.J.; Thummel, C.; Beato, M.; Herrlich, P.; Schütz, G.; Umesono, K.; Blumberg, B.; Kastner, P.; Mark, M.; Chambon, P.; Evans, R.M. The nuclear receptor super-family: The second decade. Cell, 1995, 83, 835-839.
[71]
Sarraf, P.; Mueller, E.; Jones, D.; King, F.J.; DeAngelo, D.J.; Partridge, J.B.; Holden, S.A.; Chen, L.B.; Singer, S.; Fletcher, C.; Spiegelman, B.M. Differentiation and reversal of malignant changes in colon cancer through PPAR gamma. Nat. Med., 1998, 4, 1046-1052.
[72]
Kubota, T.; Koshizuka, K.; Williamson, E.A.; Asou, H.; Said, J.W.; Holden, S.; Miyoshi, I.; Koeffler, H.P. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res., 1998, 58, 3344-3352.
[73]
Takahashi, N.; Okumura, T.; Motomura, W.; Fujimoto, Y.; Kawabata, I.; Kohgo, Y. Activation of PPAR gamma inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett., 1999, 455, 135-139.
[74]
Tan, B.S.; Kang, O.; Mai, C.W.; Tiong, K.H.; Khoo, A.S.; Pichika, M.R.; Bradshaw, T.D.; Leong, C.O. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). Cancer Lett., 2013, 336(1), 127-139.
[75]
Ranganathan, P.; Weaver, K.L.; Capobianco, A.J. Notch signalling in solid tumours: A little bit of everything but not all the time. Nat. Rev. Cancer, 2011, 11(5), 338-351.
[76]
Ray, A.; Vasudevan, S.; Sengupta, S. 6-shogaol inhibits breast cancer cells and stem cell-like spheroids by modulation of notch signaling pathway and induction of autophagic cell death. PLoS One, 2015, 10, e0137614.
[77]
Zvereva, M.I.; Shcherbakova, D.M.; Dontsova, O.A. Telomerase: structure, functions, and activity regulation. Biochemistry (Mosc.), 2010, 75, 1563-1583.
[78]
Tuntiwechapikul, W.; Taka, T.; Songsomboon, C.; Kaewtunjai, N.; Imsumran, A.; Makonkawkeyoon, L.; Pompimon, W.; Lee, T.R. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J. Med. Food, 2010, 13(6), 1347-1354.
[79]
Chandrasekharan, N.V.; Simmons, D.L. The cyclooxygenases. Genome Biol., 2004, 5(9), 2004.
[80]
Zha, S.; Yegnasubramanian, V. Nelson. W.G.; Isaacs, W.B.; De Marzo, A.M. Cyclooxygenases in cancer: Progress and perspective. Cancer Lett., 2004, 215, 1-20.
[81]
harma, S.; Stolina, M.; Yang, S.C.; Baratelli, F.; Lin, J.F.; Atianzar, K, Luo, J.; Zhu, L.; Lin, Y.; Huang, M.; Dohadwala, M.; Batra, R.K.; Dubinett, S.M. Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. Clin. Cancer Res., 2003, 9, 961-968.
[82]
Jiang, Y.; Turgeon, D.K.; Wright, B.D.; Sidahmed, E.; Ruffin, M.T.; Brenner, D.E.; Sen, A.; Zick, S.M. Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. Eur. J. Cancer Prev., 2013, 22, 455-460.
[83]
Kumar, A.; Rajendran, V.; Sethumadhavan, R.; Purohit, R. AKT kinase pathway: A leading target in cancer research. Scientif. World J., 2013, 2013, 756134.
[84]
Yu, Z.; Wan, Y.; Liu, Y.; Yang, J.; Li, L.; Zhang, W. Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells. Pharm. Biol., 2016, 54(10), 2026-2032.
[85]
Tahir, A.A.; Sani, N.F.; Murad, N.A.; Makpol, S.; Ngah, W.Z.; Yusof, Y.A. Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells. Nutr. J., 2015, 1(14), 31.
[86]
Fridman, R.; Toth, M.; Pena, D.; Mobashery, S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res., 1995, 55, 2548-2555.
[87]
Ling, H.; Yang, H.; Tan, S.H.; Chui, W.K.; Chew, E.H. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharmacol., 2010, 161(8), 1763-1777.
[88]
McFadyen, M.C.; Melvin, W.T.; Murray, G.I. Cytochrome P450 enzymes: Novel options for cancer therapeutics. Mol. Cancer Ther., 2004, 3, 363-371.
[89]
Li, M.; Chen, P.Z.; Yue, Q.X.; Li, J.Q.; Chu, R.A.; Zhang, W.; Wang, H. Pungent ginger components modulates human cytochrome P450 enzymes in vitro. Acta Pharmacol. Sin., 2013, 34(9), 1237-1242.
[90]
Yao, J.; Ge, C.; Duan, D.; Zhang, B.; Cui, X.; Peng, S.; Liu, Y.; Fang, J. Activation of the phase II enzymes for neuroprotection by ginger active constituent 6-dehydrogingerdione in PC12 cells. J. Agric. Food Chem., 2014, 62(24), 5507-5518.
[91]
Shaikh, J.; Ankola, D.; Beniwal, D.V.; Singh, D.; Kumar, M.N. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur. J. Pharm. Sci., 2009, 37, 223-230.
[92]
Zhang, M.; Xu, C.; Liu, D.; Han, M.K.; Wang, L.; Merlin, D. Oral delivery of nanoparticles loaded with ginger active compound, 6-shogaol, attenuates ulcerative colitis and promotes wound healing in a murine model of ulcerative colitis. J. Crohn’s Colitis, 2017, 12(2), 217-229.
[93]
Zhang, M.Z.; Xiao, B.; Wang, H.; Han, M.K.; Zhang, Z.; Viennois, E.; Xu, C.L.; Merlin, D. Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy. Mol. Ther., 2016, 24, 1783-1796.
[94]
Ryan, J.L.; Heckler, C.E.; Roscoe, J.A.; Dakhil, S.R.; Kirshner, J.; Flynn, P.J.; Hickok, J.T.; Morrow, G.R. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients. Support. Care Cancer, 2011, 20, 1479-1489.
[95]
Wu, H.; Ye, D.; Bai, Y.; Zhao, Y. Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats. Zhongguo Zhongyao Zazhi, 1990, 15(5), 278-280, 317-318.
[96]
Weidner, M.S.; Sigwart, K. The safety of a ginger extract in the rat. J. Ethnopharmacol., 2000, 73, 513-520.
[97]
Weidner, M.S.; Sigwart, K. Investigation of the teratogenic potential of a Zingiber officinale extract in the rat. Reprod. Toxicol., 2001, 15, 75-80.
[98]
Jeena, K.; Liju, V.B.; Kuttan, R. A preliminary 13-week oral toxicity study of ginger oil in male and female Wistar rats. Int. J. Toxicol., 2011, 30(6), 662-670.
[99]
Kapoor, V.; Aggarwal, S.; Das, S.N. 6-Gingerol Mediates its anti tumor activities in human oral and cervical cancer cell lines through apoptosis and cell cycle arrest. Phytother. Res., 2016, 30(4), 588-595.
[100]
Zhang, F.; Thakur, K.; Hu, F.; Zhang, J.G.; Wei, Z.J. 10-Gingerol, a Phytochemical Derivative from “Tongling White Ginger”, inhibits cervical cancer: Insights into the molecular mechanism and inhibitory targets. J. Agric. Food Chem., 2017, 65, 2089-2099.
[101]
Zhang, F.; Thakur, K.; Hu, F.; Zhang, J.G.; Wei, Z.J. 10-Gingerol, a phytochemical derivative from “Tongling White Ginger”, inhibits cervical cancer: insights into the molecular mechanism and inhibitory targets. J. Agric. Food Chem., 2017, 65, 2089-2099.
[102]
Rhode, J.M.; Huang, J.; Fogoros, S.; Tan, L.; Zick, S.; Liu, J.R. Ginger induces apoptosis and autophagocytosis in ovarian cancer
cells. Presented at the 97th AACR Annual Meeting, April 1-5, 2006. Washington, DC
[103]
Martin, A.C.B.M.; Fuzer, A.M.; Becceneri, A.B.; da Silva, J.A.; Tomasin, R.; Denoyer, D.; Kim, S.H.; McIntyre, K.A.; Pearson, H.B.; Yeo, B.; Nagpal, A.; Ling, X.; Selistre-de-Araújo, H.S.; Vieira, P.C.; Cominetti, M.R.; Pouliot, N. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget, 2017, 8(42), 72260-72271.
[104]
Lee, H.S.; Seo, E.Y.; Kang, N.E.; Kim, W.K. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J. Nutr. Biochem., 2008, 19, 313-319.
[105]
Bernard, M.M.; McConnery, J.R.; Hoskin, D.W. [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Exp. Mol. Pathol., 2017, 102, 370-376.
[106]
Joo, J.H.; Hong, S.S.; Cho, Y.R.; Seo, D.W. 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncol. Rep., 2016, 35, 779-784.
[107]
Hessien, M.; El-Gendy, S.; Donia, T.; Sikkena, M.A. Growth inhibition of human non-small lung cancer cells h460 by green tea and ginger polyphenols. Anticancer. Agents Med. Chem., 2012, 12(4), 383-390.
[108]
Liu, C.M.; Kao, C.L.; Tseng, Y.T.; Lo, Y.C.; Chen, C.Y. Ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cell. Molecules, 2017, 22, 1477.
[109]
Habib, S.H.; Makpol, S.; Abdul Hamid, N.A.; Das, S.; Ngah, W.Z.; Yusof, Y.A. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (São Paulo), 2008, 63, 807-813.
[110]
Al-Abbasi, F.A.; Alghamdi, E.A.; Baghdadi, M.A.; Alamoudi, A.J.; El-Halawany, A.M.; El-Bassossy, H.M.; Aseeri, A.H.; Al-Abd, A.M. Gingerol synergizes the cytotoxic effects of doxorubicin against liver cancer cells and protects from its vascular toxicity. Molecules, 2016, 21(7), E886.
[111]
Park, Y.J.; Wen, J.; Bang, S.; Park, S.W.; Song, S.Y. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med. J., 2006, 47, 688-697.
[112]
Zhou, L.; Qi, L.; Jiang, L.; Zhou, P.; Ma, J.; Xu, X.; Li, P. Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. AAPS J., 2014, 16(2), 246-257.
[113]
Huang, H.C.; Chiu, S.H.; Chang, T.M. Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action. Biosci. Biotechnol. Biochem., 2011, 75(6), 1067-1072.
[114]
Lin, C.B.; Lin, C.C.; Tsay, G.J. 6-Gingerol inhibits growth of colon cancer cell lovo via induction of G2/M arrest. Evid. Based Complement. Alternat. Med., 2012, 326096.
[115]
Zeng, H.L.; Han, X.A.; Gu, C.; Zhu, H.Y.; Huang, X.S.; Gu, J.Q.; Zhong, Q.; Liu, G.J.; Ming, W.J.; Cai, X.N. Reactive oxygen species and mitochondrial membrane potential changes in leukemia cells during 6-gingerol induced apoptosis. Zhong Yao Cai, 2010, 33(4), 584-587.
[116]
Rastogi, N.; Gara, R.K.; Trivedi, R.; Singh, A.; Dixit, P.; Maurya, R.; Duggal, S.; Bhatt, M.L.; Singh, S.; Mishra, D.P. (6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. Free Radic. Biol. Med., 2014, 68, 288-301.
[117]
Fan, J.; Yang, X.; Bi, Z. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol., 2015, 36(2), 1135-1141.
[118]
Khater, D.S. The influence of ginger as a chemopreventive agent on proliferation and apoptosis in chemically induced oral carcinogenesis. Nat. Sci., 2010, 8, 44-51.
[119]
Lee, D.H.; Kim, D.W.; Jung, C.H.; Lee, Y.J.; Park, D. Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol. Appl. Pharmacol., 2014, 279(3), 253-265.