摘要
慢性丙型肝炎(CHC)病毒感染和相关肝病仍然具有挑战性,世界各地的疾病负担仍然很大。慢性感染患者的总体治疗率“非常差”,在现实的临床环境中,聚乙二醇化干扰素(PEG-IFN)和利巴韦林(RBV)双重治疗的完成情况并不理想。第一代、第二代和下一代直接作用抗病毒药物(DAAS)的批准是丙型肝炎病毒(HCV)治疗方法在治疗CHC感染者方面的重大突破。这种固定剂量组合(FDC)或RBV的治疗方案已经证明了它们对不同HCV基因型的临床疗效,并且难以治疗特殊人群。我们继续看到新的泛基因型抗-HCV方案的发展,其持续病毒学应答(SVR;第12周或治疗结束时检测不到的病毒载量)非常高,对药物抵抗的高屏障,不良事件的发生率较低,与一些老的基于RBV的三重DAA疗法相比,药物相互作用更少。口服无干扰素DAAS似乎是治疗丙型肝炎的非常成功的战略治疗方法,并促使卫生政策制定者制定治疗优先顺序和政策,以降低丙型肝炎相关发病率和死亡率。本文全面综述了无干扰素抗-HCV方案,这些方案在一定程度上改变了丙型肝炎的治疗模式,并带来了一些额外的好处,以激励我们在不久的将来努力实现消除HCV的全球目标。
关键词: 无干扰素抗病毒药物、蛋白酶抑制剂、NS5a抑制剂、NS5b抑制剂、泛基因型治疗方案、DAA失败、HCV治疗。
Current Molecular Medicine
Title:All Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C
Volume: 18 Issue: 7
关键词: 无干扰素抗病毒药物、蛋白酶抑制剂、NS5a抑制剂、NS5b抑制剂、泛基因型治疗方案、DAA失败、HCV治疗。
摘要: Chronic hepatitis C (CHC) virus infection and associated hepatic diseases are still challenging, and the disease burden remains significant around the world. Overall treatment rates for the chronically infected patients have been “dismally poor” and that treatment completion of dual-therapy— pegylated interferon (PEG-IFN) and ribavirin (RBV) is suboptimal in the real-world clinical settings. The approval of first, second and next-generation direct-acting antivirals (DAAs) represents a major breakthrough in hepatitis C virus (HCV) therapeutics to treat CHC infected individuals. Such therapeutic regimens in a fixed dose combination (FDC) or along with RBV have proven their clinical efficacy against different HCV genotypes, and harder-to-treat special populations. We continue to see the development of novel pan-genotypic anti-HCV regimens with very high sustained virologic response (SVR; undetectable viral load at week 12 or at the end of therapy) rates, high barrier to drug resistance, low frequency of adverse events, and fewer drug-drug interactions as compared to some older RBV based triple DAA therapies. Oral interferon-free DAAs seem highly successful strategic treatment approaches against hepatitis C and impulse health policy makers to establish the treatment priorties and policies to reduce the rate of hepatitis C-related morbidity and mortality. This review article comprehensively overviews interferon-free anti-HCV regimens, which have totally shifted the treatment paradigms for hepatitis C with some additional benefits to galvanize our efforts to achieve the global goal of HCV elimination in near future.
Export Options
About this article
Cite this article as:
All Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C, Current Molecular Medicine 2018; 18 (7) . https://dx.doi.org/10.2174/1566524019666190104110439
DOI https://dx.doi.org/10.2174/1566524019666190104110439 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Modulation of Angiogenesis for Cancer Prevention: Strategies Based On Antioxidants and Copper Deficiency
Current Pharmaceutical Design Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition
Current Medicinal Chemistry Mesenchymal Epithelial Transition (MET): A Key Player in Chemotherapy Resistance and an Emerging Target for Potentiating Cancer Immunotherapy
Current Cancer Drug Targets Atherosclerosis as an Inflammatory Disease
Current Pharmaceutical Design RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease
Current Medicinal Chemistry Serum miRNAs Signature Plays an Important Role in Keloid Disease
Current Molecular Medicine Carbon Monoxide-Releasing Molecules: A Pharmacological Expedient to Counteract Inflammation
Current Pharmaceutical Design Microarray-Based Gene Expression Analysis of Hepatocellular Carcinoma
Current Genomics Subject Index to Volume 3
Mini-Reviews in Medicinal Chemistry Recent Synthetic Strategies for Monocyclic Azole Nucleus and Its Role in Drug Discovery and Development
Current Organic Synthesis The Role of Cytochrome P450 in Herb-Drug Interactions
Current Pharmacogenomics Cancer Treatment-Induced Cardiotoxicity: a Cardiac Stem Cell Disease?
Cardiovascular & Hematological Agents in Medicinal Chemistry VEGF-VEGFR System as a Target for Suppressing Inflammation and other Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives
Current Drug Metabolism Fibroblast Growth Factor Receptor Signaling in Cancer Biology and Treatment
Current Signal Transduction Therapy Dendritic Nanoparticles for Cutaneous Drug Delivery - Testing in Human Skin and Reconstructed Human Skin
Current Pharmaceutical Design Keratin-Based Biomaterials for Biomedical Applications
Current Drug Targets Targeted Drug Delivery to the Virus-Infected Airway; Complications and Remedies
Current Drug Delivery Chemokines and Chemokine Receptors Blockers as New Drugs for the Treatment of Chronic Obstructive Pulmonary Disease
Current Medicinal Chemistry Clinical Pharmacogenetics of Methotrexate
Current Drug Metabolism