摘要
天然产物是全世界治疗有效化合物的重要来源。 自远古以来,大量的植物提取物和分离的化合物已广泛用于治疗和预防人类疾病,目前,世界上超过60%的人口对植物药物寄予厚望,这从中草药疗法的数量不断增加中可以看出 在市场上。 不幸的是,用于治疗多种疾病的几种有希望的天然分子的特征是极其不利的特征,例如低水溶性和不良/不规则的生物利用度,这阻碍了它们的临床应用。 为了克服这些局限性并使草药疗法更有效,已采用了不同的配方方法。 在增加药物溶解度的不同策略中,纳米晶体可被视为最有趣和成功的方法之一。 药物纳米晶体是通常配制为纳米悬浮液的纳米级药物颗粒,即在液体介质中的亚微米分散液,其中表面活性剂,聚合物或两者的混合物均起稳定剂的作用。 在这篇综述中,我们描述了有关药物纳米晶体制剂用于递送具有显着药理活性的天然化合物的最重要结果和进展。 本书分为9个部分,每个部分都针对特定的水溶性差的天然化合物(芹菜素,槲皮素,芦丁,姜黄素,黄ical苷和黄ical素,橙皮素和橙皮苷,白藜芦醇,叶黄素,水飞蓟宾)。 为了促进这些天然纳米药物的临床翻译,我们认为未来的研究应将基本的药代动力学研究与精心设计的临床前实验结合起来,以证明制剂在体内相关动物模型中的功效。
关键词: 体内纳米晶体,纳米悬浮液,天然产物,自上而下的技术,自下而上的技术。
[http://dx.doi.org/10.1016/j.jconrel.2013.02.025] [PMID: 23474031]
[http://dx.doi.org/10.1016/j.jddst.2015.09.007]
[http://dx.doi.org/10.1093/ajcn/79.5.727] [PMID: 15113710]
[http://dx.doi.org/10.5731/pdajpst.2011.00634] [PMID: 22293237]
[http://dx.doi.org/10.1111/j.2042-7158.2010.01133.x] [PMID: 21039540]
[http://dx.doi.org/10.1016/j.ijpharm.2007.05.049] [PMID: 17658228]
[http://dx.doi.org/10.1002/jps.23031] [PMID: 22213468]
[http://dx.doi.org/10.1016/j.addr.2007.10.012] [PMID: 18155800]
[http://dx.doi.org/10.1016/S0169-409X(00)00096-X] [PMID: 11104893]
[http://dx.doi.org/10.1038/nrd1576] [PMID: 15573101]
[http://dx.doi.org/10.1016/j.ijpharm.2012.09.034] [PMID: 23000841]
[http://dx.doi.org/10.1016/j.ejpb.2011.01.007] [PMID: 21266197]
[http://dx.doi.org/10.1038/nrd1494] [PMID: 15340388]
[http://dx.doi.org/10.2174/1381612821666151027152350] [PMID: 26503149]
[http://dx.doi.org/10.1016/0378-5173(95)00033-F]
[http://dx.doi.org/10.1201/b14005-13]
[http://dx.doi.org/10.1016/0378-5173(95)00122-Y]
[http://dx.doi.org/10.1016/j.ijpharm.2009.01.024] [PMID: 19429297]
[http://dx.doi.org/10.1016/j.ijpharm.2011.04.034] [PMID: 21540090]
[http://dx.doi.org/10.1016/S0378-5173(02)00114-X] [PMID: 12062503]
[http://dx.doi.org/10.1080/03639040802623941]
[http://dx.doi.org/10.3109/03639041003695139] [PMID: 20545506]
[http://dx.doi.org/10.1016/j.ijpharm.2007.02.030] [PMID: 17398045]
[http://dx.doi.org/10.1016/j.ijpharm.2007.12.016] [PMID: 18242896]
[http://dx.doi.org/10.1016/j.ijpharm.2008.09.022] [PMID: 18848873]
[http://dx.doi.org/10.1016/S0928-0987(02)00251-8] [PMID: 12594003]
[http://dx.doi.org/10.3109/03639045.2010.551775] [PMID: 21323486]
[http://dx.doi.org/10.1016/j.ces.2011.11.010]
[PMID: 18990939]
[http://dx.doi.org/10.1016/j.addr.2007.05.003] [PMID: 17601629]
[http://dx.doi.org/10.1016/j.addr.2011.03.011] [PMID: 21457742]
[http://dx.doi.org/10.1016/j.ijpharm.2009.11.007] [PMID: 19922777]
[http://dx.doi.org/10.1016/j.ijpharm.2010.10.055] [PMID: 21056643]
[http://dx.doi.org/10.1016/j.ijpharm.2013.10.007] [PMID: 24135683]
[http://dx.doi.org/10.1016/j.ijpharm.2014.08.017] [PMID: 25138256]
[http://dx.doi.org/10.1021/ie900248f]
[http://dx.doi.org/10.1080/03639040500534184] [PMID: 16908423]
[http://dx.doi.org/10.1016/S1773-2247(04)50051-5]
[http://dx.doi.org/10.1016/j.ijpharm.2005.06.027] [PMID: 16109466]
[http://dx.doi.org/10.1016/j.jconrel.2008.03.002] [PMID: 18423767]
[http://dx.doi.org/10.1023/A:1020390422785] [PMID: 12403063]
[http://dx.doi.org/10.1016/j.ijpharm.2009.03.029] [PMID: 19481696]
[http://dx.doi.org/10.1016/S0928-0987(03)00203-3] [PMID: 14592695]
[http://dx.doi.org/10.1016/j.intimp.2011.03.012] [PMID: 21443976]
[http://dx.doi.org/10.1016/j.foodchem.2016.03.052] [PMID: 27041302]
[http://dx.doi.org/10.1080/10717544.2017.1399302] [PMID: 29115900]
[http://dx.doi.org/10.1016/j.ijpharm.2012.07.002] [PMID: 22796171]
[http://dx.doi.org/10.1016/j.ijpharm.2011.08.018] [PMID: 21871547]
[PMID: 21284256]
[http://dx.doi.org/10.1016/j.ijpharm.2014.11.008] [PMID: 25448550]
[http://dx.doi.org/10.1016/j.ejps.2012.12.026] [PMID: 23305994]
[http://dx.doi.org/10.1093/ajcn/74.4.418] [PMID: 11566638]
[http://dx.doi.org/10.1016/j.fct.2007.05.015] [PMID: 17698276]
[http://dx.doi.org/ 10.3892/ijmm.16.2.275] [PMID: 16012761]
[http://dx.doi.org/10.1016/j.mrgentox.2008.04.008] [PMID: 18556240]
[http://dx.doi.org/10.2174/09298673113209990120] [PMID: 23514412]
[http://dx.doi.org/10.3390/pharmaceutics3030497] [PMID: 24310593]
[http://dx.doi.org/10.3109/10717544.2014.923956] [PMID: 24937381]
[http://dx.doi.org/10.1016/j.ijpharm.2009.05.047] [PMID: 19501147]
[http://dx.doi.org/10.1080/03639040802526805] [PMID: 19514988]
[http://dx.doi.org/10.1016/j.ejpb.2011.08.006] [PMID: 21896330]
[http://dx.doi.org/10.1016/j.carbpol.2014.11.070] [PMID: 25659692]
[http://dx.doi.org/10.1208/s12249-010-9525-6] [PMID: 20936440]
[http://dx.doi.org/10.1016/j.ejpb.2008.06.032] [PMID: 18667164]
[http://dx.doi.org/10.1016/j.tifs.2017.07.008]
[http://dx.doi.org/10.1016/j.ijpharm.2008.11.029] [PMID: 19114097]
[http://dx.doi.org/10.1016/j.ejps.2008.12.002] [PMID: 19130880]
[http://dx.doi.org/10.1007/s40005-013-0084-1]
[http://dx.doi.org/10.3390/cosmetics3010009]
[http://dx.doi.org/10.1016/j.ijpharm.2016.05.017] [PMID: 27265313]
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[http://dx.doi.org/10.3390/foods6100092] [PMID: 29065496]
[http://dx.doi.org/10.1208/s12248-012-9432-8] [PMID: 23143785]
[http://dx.doi.org/10.1016/j.jconrel.2016.01.018] [PMID: 26778694]
[http://dx.doi.org/10.1021/acs.jmedchem.6b00975] [PMID: 28074653]
[http://dx.doi.org/10.1016/j.biomaterials.2013.12.090] [PMID: 24439402]
[http://dx.doi.org/10.3109/10717544.2010.520353] [PMID: 20939679]
[http://dx.doi.org/10.1016/j.ejps.2013.03.010] [PMID: 23542494]
[http://dx.doi.org/10.1016/j.colsurfb.2015.01.027] [PMID: 25660094]
[http://dx.doi.org/10.1111/jphp.12575] [PMID: 27283220]
[http://dx.doi.org/10.1016/j.drudis.2017.01.016] [PMID: 28189800]
[http://dx.doi.org/10.1080/10717544.2016.1233589] [PMID: 28155567]
[http://dx.doi.org/10.1016/j.jcis.2016.09.003] [PMID: 27657837]
[http://dx.doi.org/10.1007/s11434-016-1136-5] [PMID: 27730005]
[http://dx.doi.org/10.3390/ijms17101681] [PMID: 27735841]
[http://dx.doi.org/10.1211/002235702522] [PMID: 12631413]
[http://dx.doi.org/10.1211/0022357001777621] [PMID: 11197087]
[http://dx.doi.org/10.2147/IJN.S44924] [PMID: 23976849]
[http://dx.doi.org/10.1016/S1875-5364(14)60012-1] [PMID: 24484600]
[http://dx.doi.org/10.3390/molecules21091149] [PMID: 27589712]
[http://dx.doi.org/10.1016/j.ijpharm.2012.12.036] [PMID: 23291447]
[http://dx.doi.org/10.1016/j.ijpharm.2011.08.023] [PMID: 21878378]
[http://dx.doi.org/10.1002/ptr.1074] [PMID: 11746857]
[http://dx.doi.org/10.1016/j.lfs.2014.07.029] [PMID: 25109791]
[http://dx.doi.org/10.1016/j.ijpharm.2008.12.030] [PMID: 19162147]
[http://dx.doi.org/10.1021/mp5008647] [PMID: 25785392]
[http://dx.doi.org/10.1016/j.ijpharm.2014.11.039] [PMID: 25448556]
[http://dx.doi.org/10.1155/2015/837042] [PMID: 26221416]
[http://dx.doi.org/10.1007/s10847-006-9047-8]
[http://dx.doi.org/10.1016/j.colsurfb.2013.06.016] [PMID: 23838200]
[PMID: 20099519]
[PMID: 22312699]
[PMID: 27220078]
[http://dx.doi.org/10.1208/s12249-017-0742-0] [PMID: 28243886]
[http://dx.doi.org/10.1007/s13346-017-0362-y] [PMID: 28194730]
[http://dx.doi.org/10.3233/BME-181729] [PMID: 29578462]
[http://dx.doi.org/10.1371/journal.pone.0126599] [PMID: 25965695]
[http://dx.doi.org/10.1016/j.clindermatol.2008.01.011] [PMID: 19168000]
[http://dx.doi.org/10.1016/j.ijpharm.2011.08.026] [PMID: 21884768]
[http://dx.doi.org/10.1016/j.toxlet.2003.10.031] [PMID: 15068825]
[http://dx.doi.org/10.1161/01.STR.0000132197.67350.bd] [PMID: 15178820]
[http://dx.doi.org/10.1046/j.1365-2796.2002.00973.x] [PMID: 11982737]
[http://dx.doi.org/10.1046/j.0022-202X.2004.22227.x] [PMID: 15009738]
[http://dx.doi.org/10.1159/000101807] [PMID: 17446716]
[http://dx.doi.org/10.1016/j.ijpharm.2007.11.062] [PMID: 18242898]
[http://dx.doi.org/10.1002/jps.2600821008] [PMID: 8254497]
[http://dx.doi.org/10.1016/j.etap.2014.05.005] [PMID: 24934613]
[http://dx.doi.org/10.1016/j.freeradbiomed.2012.02.008] [PMID: 22343419]
[http://dx.doi.org/10.3892/mmr.2014.2821] [PMID: 25355274]
[http://dx.doi.org/10.1002/ptr.3207] [PMID: 20564545]
[http://dx.doi.org/10.1111/j.1572-0241.1998.00139.x] [PMID: 9468229]
[http://dx.doi.org/10.4103/0973-1296.141799] [PMID: 25422558]
[PMID: 9855566]
[http://dx.doi.org/10.1002/(SICI)1099-0844(199703)15:1<27:AID-CBF714>3.0.CO;2-W] [PMID: 9075334]
[http://dx.doi.org/10.1088/0957-4484/21/15/155104] [PMID: 20332565]
[http://dx.doi.org/10.1016/j.canlet.2011.03.028] [PMID: 21507570]
[http://dx.doi.org/10.2147/DDDT.S133806] [PMID: 28553075]
[http://dx.doi.org/10.1128/AAC.50.3.1096-1099.2006] [PMID: 16495278]
[PMID: 25866771]