摘要
背景：慢性疼痛在老年人中很常见，并且与基于横断面研究的认知功能障碍有关。然而，基于社区的样本中慢性疼痛与痴呆之间的纵向关联尚不清楚。 目的：我们的目的是评估疼痛强度和疼痛干扰与老年人社区样本中痴呆症的关系。 方法：参与者是来自爱因斯坦老龄化研究（EAS）的年龄为118岁或以上的1,114个人，这是一项针对纽约布朗克斯县社区居住老年人的纵向队列研究。主要结局指标是使用DSM-IV标准诊断的痴呆事件。使用来自SF-36调查问卷的项目测量第一次年度访问前一个月的疼痛强度和干扰。疼痛强度和疼痛干扰被评估为使用Cox比例风险模型同时控制潜在混杂因素的痴呆时间的预测因子。 结果：在参与者中，114名患者在平均4。4年（SD = 3.1）的随访中发生痴呆。模型显示疼痛强度对发展痴呆的时间没有显着影响，而较高水平的疼痛干扰与较高的痴呆风险相关。在包括疼痛强度和干扰作为事件性痴呆的预测因子的模型中，疼痛干扰对事件性痴呆具有显着影响，并且疼痛强度仍然不显着。 结论：作为一种潜在的可修复的危险因素，将疼痛干扰与认知衰退联系起来的机制值得进一步探索。
关键词: 疼痛强度，疼痛干扰，痴呆，阿尔茨海默病，可补救的危险因素。
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