摘要
膜蛋白在体内起着重要的生理作用，是药物的主要靶点。膜蛋白的研究是药物发现的重要组成部分。生物过程是一个循环网络，膜蛋白是网络中的一个重要枢纽，因为大多数药物通过与膜蛋白的相互作用达到治疗效果。本文综述了典型的膜蛋白靶点，包括gpcrs、转运体和离子通道。此外，我们还总结了涉及药物、药物目标信息及其相关数据的网络服务器和数据库。此外，我们主要介绍了现代药物的发展和实践，特别是展示了一系列最先进的计算模型，包括基于网络的方法和基于机器学习的方法，并展示了当代的成果。最后，我们讨论了药物再利用和药物发现的未来方向，并提出了生物活性数据的改进框架、建立或改进的预测方法、药物生物活性的替代理解方法及其生物过程。
关键词: 膜蛋白，药物目标，药物发现，计算生物学，机器学习，生物网络。
图形摘要
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