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Review Article

纳米颗粒-细胞膜的相互作用:热力学，毒性和细胞反应

卷 27, 期 20, 2020

页: [3330 - 3345] 页: 16

弟呕挨: 10.2174/0929867325666181112090648

价格: $65

摘要

纳米材料已经成为我们日常生活的一部分，特别是包含在食品、水、化妆品、添加剂和纺织品中的纳米颗粒。纳米颗粒在细胞水平上与生物体相互作用。细胞膜是对抗纳米颗粒潜在毒性作用的第一道保护屏障。这是第一次接触，包括细胞膜和相关蛋白质之间的相互作用和纳米颗粒在这里进行了批判性的回顾。纳米颗粒，取决于它们的毒性，可以导致细胞生理改变，例如细胞信号中断或基因表达改变，它们还可以触发免疫反应，甚至凋亡。此外，纳米颗粒-膜和纳米颗粒-蛋白质-膜相互作用背后的基本热力学也进行了讨论。分析的目的是增加我们对这些交互所涉及的机制的了解。最后，对结果进行回顾和讨论。

关键词: 纳米粒子-质膜相互作用，纳米粒子-蛋白质相互作用，热力学，毒性，细胞反应，细胞膜。

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