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General Review Article

环状RNA作为癌症的新型生物标志物和治疗靶点

卷 19, 期 2, 2019

页: [125 - 133] 页: 9

弟呕挨: 10.2174/1566523218666181109142756

价格: $65

摘要

环状RNA（circRNA）是一类非编码RNA（ncRNA），其与线性RNA不同，在结构上形成没有5''-末端帽和3''-末端poly（A）尾的闭环。 CircRNA广泛存在于真核细胞中，具有结构稳定性，高丰度和细胞/组织特异性表达的能力。 越来越多的研究表明，失调的circRNA与癌症的发生和发展密切相关。 在这篇综述中，我们主要讨论癌组织，血浆和外泌体中差异表达的circRNA，这使得临床医生可以使用某些circRNA作为癌症诊断和预后的新型生物标志物。 特别是，我们主要关注circRNA作为潜在的治疗靶点，这将为癌症基因治疗提供有希望的应用。

关键词: CircRNAs，差异表达，外泌体，循环RNA，生物标志物，治疗靶标，癌症。

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图形摘要

[1]
Dunham I, Kundaje A, Aldred SF, et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012; 489(7414): 57-74.
[2]
Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature 1979; 280(5720): 339-40.
[3]
Arnberg AC, Van Ommen GJ, Grivell LA, Van Bruggen EF, Borst P. Some yeast mitochondrial RNAs are circular. Cell 1980; 19(2): 313-9.
[4]
Cocquerelle C, Mascrez B, Hetuin D, Bailleul B. Mis-splicing yields circular RNA molecules. FASEB J 1993; 7(1): 155-60.
[5]
Nigro JM, Cho KR, Fearon ER, et al. Scrambled exons. Cell 1991; 64(3): 607-13.
[6]
Lu T, Cui L, Zhou Y, et al. Transcriptome-wide investigation of circular RNAs in rice. RNA 2015; 21(12): 2076-87.
[7]
Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. BMC Genomics 2015; 16: 454.
[8]
Danan M, Schwartz S, Edelheit S, Sorek R. Transcriptome-wide discovery of circular RNAs in Archaea. Nucleic Acids Res 2012; 40(7): 3131-42.
[9]
Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 2013; 19(2): 141-57.
[10]
Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013; 495(7441): 333-8.
[11]
Zhang Y, Liang W, Zhang P, et al. Circular RNAs: Emerging cancer biomarkers and targets. J Exp Clin Cancer Res 2017; 36(1): 152.
[12]
Gao Y, Wang J, Zheng Y, Zhang J, Chen S, Zhao F. Comprehensive identification of internal structure and alternative splicing events in circular RNAs. Nat Commun 2016; 7: 12060.
[13]
Gao Y, Wang J, Zhao F. CIRI: An efficient and unbiased algorithm for de novo circular RNA identification. Genome Biol 2015; 16: 4.
[14]
Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell 2013; 51(6): 792-806.
[15]
Qu S, Yang X, Li X, et al. Circular RNA: A new star of noncoding RNAs. Cancer Lett 2015; 365(2): 141-8.
[16]
Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of CircRNAs. Cell 2015; 160(6): 1125-34.
[17]
Fang S, Guo H, Cheng Y, et al. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Cell Death Dis 2018; 9(3): 396.
[18]
Han YN, Xia SQ, Zhang YY, Zheng JH, Li W. Circular RNAs: A novel type of biomarker and genetic tools in cancer. Oncotarget 2017; 8(38): 64551-63.
[19]
Li J, Yang J, Zhou P, et al. Circular RNAs in cancer: Novel insights into origins, properties, functions and implications. Am J Cancer Res 2015; 5(2): 472-80.
[20]
Wang J, Li H. CircRNA circ_0067934 silencing inhibits the proliferation, migration and invasion of NSCLC cells and correlates with unfavorable prognosis in NSCLC. Eur Rev Med Pharmacol Sci 2018; 22(10): 3053-60.
[21]
Bahn JH, Zhang Q, Li F, et al. The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem 2015; 61(1): 221-30.
[22]
Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature 2013; 495(7441): 384-8.
[23]
Guo JU, Agarwal V, Guo H, Bartel DP. Expanded identification and characterization of mammalian circular RNAs. Genome Biol 2014; 15(7): 409.
[24]
Hansen TB, Kjems J, Damgaard CK. Circular RNA and miR-7 in cancer. Cancer Res 2013; 73(18): 5609-12.
[25]
Reddy SD, Ohshiro K, Rayala SK, Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res 2008; 68(20): 8195-200.
[26]
Saydam O, Senol O, Wurdinger T, et al. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res 2011; 71(3): 852-61.
[27]
Zhang X, Hu S, Zhang X, et al. MicroRNA-7 arrests cell cycle in G1 phase by directly targeting CCNE1 in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 2014; 443(3): 1078-84.
[28]
Jiang L, Liu X, Chen Z, et al. MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochem J 2010; 432(1): 199-205.
[29]
Sang M, Meng L, Sang Y, et al. Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression. Cancer Lett 2018; 426: 37-46.
[30]
Su C, Han Y, Zhang H, et al. CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-kappaB signalling. J Cell Mol Med 2018; 22(6): 3097-107.
[31]
Pan H, Li T, Jiang Y, et al. Overexpression of Circular RNA ciRS-7 abrogates the tumor suppressive effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT signaling pathway. J Cell Biochem 2018; 119(1): 440-6.
[32]
Chen G, Shi Y, Liu M, Sun J. circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. Cell Death Dis 2018; 9(2): 175.
[33]
Li Y, Zheng F, Xiao X, et al. CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. EMBO Rep 2017; 18(9): 1646-59.
[34]
Zheng Q, Bao C, Guo W, et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun 2016; 7: 11215.
[35]
Yang W, Du WW, Li X, Yee AJ, Yang BB. Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis. Oncogene 2016; 35(30): 3919-31.
[36]
Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res 2016; 44(6): 2846-58.
[37]
Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J 2017; 38(18): 1402-12.
[38]
Yang Q, Du WW, Wu N, et al. A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. Cell Death Differ 2017; 24(9): 1609-20.
[39]
Wang Y, Wang Z. Efficient backsplicing produces translatable circular mRNAs. RNA 2015; 21(2): 172-9.
[40]
Schneider T, Bindereif A. Circular RNAs: Coding or noncoding? Cell Res 2017; 27(6): 724-5.
[41]
Zhang M, Huang N, Yang X, et al. A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene 2018; 37(13): 1805-14.
[42]
Zhang M, Xin Y. Circular RNAs: A new frontier for cancer diagnosis and therapy. J Hematol Oncol 2018; 11(1): 21.
[43]
Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung cancer. Nat Rev Dis Primers 2015; 1: 15009.
[44]
Carninci P, Kasukawa T, Katayama S, et al. The transcriptional landscape of the mammalian genome. Science 2005; 309(5740): 1559-63.
[45]
Zong L, Sun Q, Zhang H, et al. Increased expression of circRNA_102231 in lung cancer and its clinical significance. Biomed Pharmacother 2018; 102: 639-44.
[46]
Hang D, Zhou J, Qin N, et al. A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer. Cancer Med 2018; 7(6): 2783-91.
[47]
Guarnerio J, Bezzi M, Jeong JC, et al. Oncogenic role of fusion-CircRNAs derived from cancer-associated chromosomal translocations. Cell 2016; 165(2): 289-302.
[48]
Tan S, Gou Q, Pu W, et al. Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer. Cell Res 2018; 28(6): 693-5.
[49]
Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A, Bray F. Bladder cancer incidence and mortality: A global overview and recent trends. Eur Urol 2017; 71(1): 96-108.
[50]
Yang C, Yuan W, Yang X, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer 2018; 17(1): 19.
[51]
Torre LA, Bray F, Siegel RL, et al. CA Cancer J Clin 2015; 65(2): 87-108.
[52]
Chen D, Zhang C, Lin J, Song X, Wang H. Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma. Cancer Manag Res 2018; 10: 1275-83.
[53]
Yu J, Xu QG, Wang ZG, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol 2018; 68(6): 1214-27.
[54]
Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med 2018; 96(1): 85-96.
[55]
Zhang J, Liu H, Hou L, et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer 2017; 16(1): 151.
[56]
Zhao Q, Chen S, Li T, Xiao B, Zhang X. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal 2018; 32(4)e22333
[57]
Huang M, He YR, Liang LC, Huang Q, Zhu ZQ. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol 2017; 23(34): 6330-8.
[58]
Chen S, Li T, Zhao Q, Xiao B, Guo J. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta 2017; 466: 167-71.
[59]
Zhuo F, Lin H, Chen Z, Huang Z, Hu J. The expression profile and clinical significance of circRNA0003906 in colorectal cancer. OncoTargets Ther 2017; 10: 5187-93.
[60]
Wang F, Wang J, Cao X, Xu L, Chen L. Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression. Biomed Pharmacother 2018; 98: 775-82.
[61]
Kun-Peng Z, Xiao-Long M, Chun-Lin Z. Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1. Int J Biol Sci 2018; 14(3): 321-30.
[62]
Li W, Zhong C, Jiao J, et al. Characterization of hsa_circ_0004277 as a new biomarker for acute myeloid leukemia via circular RNA profile and bioinformatics analysis. Int J Mol Sci 2017; 18(3)E597
[63]
Xuan L, Qu L, Zhou H, et al. Circular RNA: A novel biomarker for progressive laryngeal cancer. Am J Transl Res 2016; 8(2): 932-9.
[64]
Xia W, Qiu M, Chen R, et al. Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation. Sci Rep 2016; 6: 35576.
[65]
Vitiello M, Tuccoli A, Poliseno L. Long non-coding RNAs in cancer: implications for personalized therapy. Cell Oncol (Dordr) 2015; 38(1): 17-28.
[66]
Hsiao KY, Lin YC, Gupta SK, et al. Noncoding effects of circular RNA CCDC66 promotes colon cancer growth and metastasis. Cancer Res 2017; 77(9): 2339-50.
[67]
Tian H, Zhou C, Yang J, Li J, Gong Z. Long and short noncoding RNAs in lung cancer precision medicine: Opportunities and challenges. Tumour Biol 2017; 39(4)1010428317697578
[68]
Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 2015; 22(3): 256-64.
[69]
Yang J, Meng X, Pan J, et al. CRISPR/Cas9-mediated noncoding RNA editing in human cancers. RNA Biol 2018; 15(1): 35-43.
[70]
Salsman J, Masson JY, Orthwein A, Dellaire G. CRISPR/Cas9 gene editing: From basic mechanisms to improved strategies for enhanced genome engineering in vivo. Curr Gene Ther 2017; 17(4): 263-74.
[71]
Piwecka M, Glazar P, Hernandez-Miranda LR, et al. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science 2017; 357(6357)eaam8526
[72]
Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna JA. RNA-dependent RNA targeting by CRISPR-Cas9. eLife 2018; 7e32724
[73]
Han D, Li J, Wang H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology 2017; 66(4): 1151-64.
[74]
Li X, Wang J, Zhang C, et al. Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. J Pathol 2018; 246(2): 166-79.
[75]
Kristensen LS, Hansen TB, Veno MT, Kjems J. Circular RNAs in cancer: Opportunities and challenges in the field. Oncogene 2018; 37(5): 555-65.
[76]
Kamerkar S, LeBleu VS, Sugimoto H, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature 2017; 546(7659): 498-503.
[77]
Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res 2015; 25(8): 981-4.
[78]
Dou Y, Cha DJ, Franklin JL, et al. Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Sci Rep 2016; 6: 37982.
[79]
Li Z, Yanfang W, Li J, et al. Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Lett 2018; 432: 237-50.
[80]
Judge AD, Robbins M, Tavakoli I, et al. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest 2009; 119(3): 661-73.
[81]
Du WW, Fang L, Yang W, et al. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Cell Death Differ 2017; 24(2): 357-70.
[82]
Rybak-Wolf A, Stottmeister C, Glazar P, et al. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 2015; 58(5): 870-85.
[83]
Gao Y, Zhao F. Computational strategies for exploring circular RNAs. Trends Genet 2018; 34(5): 389-400.

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