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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Transition Metal-free Trifluoroethoxylation of Diaryliodonium Salts and Fluoro Alcohols

Author(s): Jian Li*, Zhengbing Wang, Xuechen Lu, Jing Lin, Li Liu and Yue Zhao

Volume 16, Issue 6, 2019

Page: [485 - 490] Pages: 6

DOI: 10.2174/1570178615666181108111232

Price: $65

Abstract

A method for the synthesis of aryl trifluoroethyl ethers from fluoroalcohols and diaryliodonium salts in the presence of NaH and warm 1,2-dichloroethane has been developed. This transition metal free reaction is mild and facile. Various functional group including electron-withdrawing and electron-donating substrates in the diaryliodonium salts were tolerated in this transformation to afford the products in moderate to high yields.

Keywords: Diaryliodonium salts, transition metal free reactions, trifluoroethoxylation, organic compound, DMSO, HMPA.

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