Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets

Title:Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets

Volume: 15 Issue: 3

Author(s): S. Praveenkumar*, S. Nath Srigitha, Ram G. Dinesh and R. Ramesh

Affiliation:

• Department of Electronics and Communication Engineering, Saveetha Engineering College, Chennai, Tamilnadu,India

Keywords: Microfluidics, biomolecule separation, dielectrophoresis, computational modeling, RBC, platelets.

Abstract:

Background: In this paper, the design and computational modeling of microfluidic channel capable of separating platelets and Red Blood Cell (RBC) from the other blood cells are proposed.

Materials and Methods: Separation based on their sizes is made possible by utilizing negative dielectrophoretic (n-DEP) force in fusion with drag force. An array of 38º angled electrode separated by 70 μm distance is designed within the microchannel and analyzed for non-uniform electric field distribution.

Results and Conclusion: The molecule movement within the microchannel under induced electric field is simulated to demonstrate the separation using the particle trajectories module. A numerical study is performed for the calculation of Clausius Mossotti (CM) factor, n-DEP force and drag force.

Cite this article as:

Praveenkumar S. *, Srigitha Nath S. , Dinesh G. Ram and Ramesh R. , Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets, Current Signal Transduction Therapy 2020; 15 (3) . https://dx.doi.org/10.2174/1574362413666181102113636