摘要
细胞周期蛋白依赖性激酶9（CDK9）作为丝氨酸/苏氨酸激酶属于大量CDK。 CDK9是PTEF-b复合物的主要核心，并且除了在许多生理过程中调节基因转录延伸的其他转录因子外，磷酸化RNA聚合酶（RNAP）II。 CDK9在多种细胞途径中的多功能特性提出它是一种吸引人的目标。 在这篇综述中，我们总结了最近关于CDK9与关键参与分子的分子相互作用的调查结果，以调节它们在各种疾病中的活性。 此外，所提出的综述提供了支持使用CDK9作为关键疾病临床开发的治疗靶点的理由; 特别是癌症将被审查。
关键词: 关键词: CDK9，心脏通路，癌症，病毒因子，纤维化，炎症，RNAP。
图形摘要
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