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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

脑网络连接介导健康老年人教育相关认知表现

卷 16, 期 1, 2019

页: [19 - 28] 页: 10

弟呕挨: 10.2174/1567205015666181022094158

价格: $65

摘要

背景: 衰老和阿茨海默症相关认知能力下降的保护因素中，教育水平是最突出的因素之一。然而，教育对认知保护作用机制仍有待阐明。本研究旨在系统评估静息状态脑网络的功能连接（FC）在教育认知保护效应中的作用。 方法: 数据由北京市77名认知正常老年人的静息状态神经心理测试和功能磁共振成像中获取。通过独立成分分析，提取了6个与初级功能或复杂认知相关的静息状态网络。然后，我们探讨了这些网络与教育水平、认知和功能性行为之间的关系。 结果: 我们发现，教育水平与广泛的复杂认知领域（包括一般心理状态、情景记忆、语言、注意力、执行功能和视觉空间处理）呈正相关，与和复杂认知有关的默认模式网络（DMN）和左额叶-顶叶网络相关。DMN的区域连通性与情景记忆能力呈显著负相关。进一步的媒介分析表明，高等教育水平与通过DMN的低区域连通性较高的情景记忆表现相关。 结论: 研究结果表明，与复杂认知相关的静息状态脑网络中的抑制性调制是教育在正常衰老过程中对认知发挥保护作用的主要途径之一。

关键词: 教育，复杂认知，静息状态脑网络，功能连接，认知储备，默认模式网络

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