摘要
外显子在癌细胞与其周围环境之间的细胞间通讯中起着至关重要的作用。这些分泌的纳米小体可以转移不同的货物,如mRNAs、蛋白质和microrn。给受体细胞的(MiRNA)。从肿瘤细胞衍生的外显子miRNAs(ExosomalmiRNAs)已成为通过免疫系统反应受损、肿瘤生长、转移而促进癌症发展的关键因素,血管生成和化疗耐药。此外,由于肿瘤细胞mirna表达失调可以通过从体液中提取的外显子R来反映。对于癌症患者,他们可以被认为是非侵入性诊断,预后和预测生物标记物.此外,由于exomiRs在促进癌症中的关键作用,对各种肿瘤都有靶向作用。外胚生物发生、miRNA分选或负载等方面被认为是一种新的肿瘤治疗方法。首先,本文综述了外显子的生物合成和生物贩运。以及它们的分离、特征和内容。接下来,介绍exomiR在肿瘤促进中的作用及其作为肿瘤生物标志物和治疗药物的应用研究进展。c审查目标。
关键词: 生物标志物,癌症治疗,外显子,基因治疗,miRNA。
Current Gene Therapy
Title:ExomiRs: A Novel Strategy in Cancer Diagnosis and Therapy
Volume: 18 Issue: 6
关键词: 生物标志物,癌症治疗,外显子,基因治疗,miRNA。
摘要: Exosomes play a critical role in intercellular communication between cancer cells and their environments. These secreted nanovesicles can transfer different cargos such as mRNAs, proteins and microRNA (miRNA) to recipient cells. Exosomal miRNAs (exomiRs) derived from tumor cells have emerged as key players in cancer promotion via impairment of the immune system response, tumor growth, metastasis, angiogenesis, and chemotherapeutic drug resistance. Moreover, since dysregulation of miRNA expression in tumor cells can be reflected by distinct profiles of exomiRs extracted from the bodily fluids of cancer patients, they can be considered as non-invasive diagnostic, prognostic and predictive biomarkers. Additionally, due to the critical roles of exomiRs in cancer promotion, targeting of various aspects of exosome biogenesis, miRNA sorting or loading has been suggested as a novel approach for cancer therapy. Firstly, this review aims to describe the biosynthesis and trafficking of exosomes as well as their isolation, characterization and content. Next, the recent advances on the role of exomiRs in cancer promotion as well as the application of exomiR as a cancer biomarker and therapeutic target are reviewed.
Export Options
About this article
Cite this article as:
ExomiRs: A Novel Strategy in Cancer Diagnosis and Therapy, Current Gene Therapy 2018; 18 (6) . https://dx.doi.org/10.2174/1566523218666181017163204
DOI https://dx.doi.org/10.2174/1566523218666181017163204 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Influence of Aldo-keto Reductase 1C3 in Prostate Cancer - A Mini Review
Current Cancer Drug Targets Tumor Initiating Cells
Current Pharmaceutical Biotechnology PPARγ and Early Human Placental Development
Current Medicinal Chemistry Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
Recent Patents on Anti-Cancer Drug Discovery Mesenchymal Stem Cells for Anti-Cancer Drug Delivery
Recent Patents on Anti-Cancer Drug Discovery Lectin-Carbohydrate Interactions: Implications for the Development of New Anticancer Agents
Current Medicinal Chemistry The Cytoprotective and Anti-cancer Potential of Bisbenzylisoquinoline Alkaloids from <I>Nelumbo nucifera</I>
Current Topics in Medicinal Chemistry Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise
Current Pharmaceutical Design The Use of Herbal Medicine in Cancer-related Anorexia/ Cachexia Treatment Around the World
Current Pharmaceutical Design Genetic Surgery - A Right Strategy to Attack Cancer
Current Gene Therapy Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin
Recent Patents on Anti-Cancer Drug Discovery Quantitative Structure-Activity Relationship Studies: Understanding the Mechanism of Tyrosine Kinase Inhibition
Current Enzyme Inhibition Targeted Taxane Delivery Systems: Recent Advances
Drug Delivery Letters Cannabinoids as Analgesic Agents: Evidence from In Vivo Studies
Current Neuropharmacology Synthetic Lethality and PARP-Inhibitors in Oral and Head & Neck Cancer
Current Pharmaceutical Design Assessment In Vitro of a Novel Therapeutic Strategy for Glioma, Combining Herpes Simplex Virus HSV1716-mediated Oncolysis with Gene Transfer and Targeted Radiotherapy
Medicinal Chemistry Nucleic Acid-Based Therapeutics for Glioblastoma
Anti-Cancer Agents in Medicinal Chemistry The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy
Anti-Cancer Agents in Medicinal Chemistry Evaluation of Non-Coding RNAs as Potential Targets in Head and Neck Squamous Cell Carcinoma Cancer Stem Cells
Current Drug Targets Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials
Current Pharmaceutical Design