Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: The Nutrigenomic Approach

doi:10.2174/0929867325666181015145225
摘要

接受心脏和非心脏手术的肥胖患者数量正在迅速增加，因为他们更容易并发疾病，如糖尿病、血栓、睡眠呼吸障碍、心脑血管疾病。即使已经有指导方针来管理肥胖患者的麻醉和手术，在未来几年，对过度肥胖外科患者心脏和大脑疾病的围手术期发病率和死亡率的评估仍将是一个挑战。本综述将概述健康和病态肥胖患者围手术期心脑轴(HBA)易损性的新机制。最后,我们将描述营养基因组学的方法,一个新兴的饮食工具,保持一个健康的体重,减少HBA受伤倾向接受所有类型的手术的肥胖个体的个性化摄入的植物化合物调节开关从健康到疾病的表观遗传方式。我们的综述提供了关于肥胖外科患者HBA反应机制的最新见解，以及它们是如何被表观遗传活性食物成分调节的。
关键词: 心脏保护，表观遗传学，功能性食品，神经保护作用，肥胖，围手术期医学。
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DOI https://dx.doi.org/10.2174/0929867325666181015145225	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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